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Application of (+)-guaiacylglycerol-beta-ferulic acid ether in preparation of medicine for treating CKD

A technology that creates woody glycerol and ferulic acid ether, which is applied in the direction of drug combinations, pharmaceutical formulas, medical preparations containing active ingredients, etc., and can solve problems such as unreported applications

Active Publication Date: 2022-07-08
NORTHWEST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The application of (+)-guaiacoylglycerol-β-ferulic acid ether in disease treatment has not been reported in the prior art

Method used

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  • Application of (+)-guaiacylglycerol-beta-ferulic acid ether in preparation of medicine for treating CKD
  • Application of (+)-guaiacylglycerol-beta-ferulic acid ether in preparation of medicine for treating CKD
  • Application of (+)-guaiacylglycerol-beta-ferulic acid ether in preparation of medicine for treating CKD

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0015] Example: (+)-Guaiacylglycerol-β-ferulic acid ether treatment of UUO mice

[0016] 1. Research Proposal

[0017] Group setting: 24 male C57BL / 6 mice (5-7 weeks) weighing 20-25g were purchased from the Experimental Animal Center of the Medical Department of Xi'an Jiaotong University, and the mice were randomly divided into sham operation group, UUO group and UUO+(+) - Guaiacylglycerol-β-ferulic ether treatment group.

[0018] Construction of UUO model: before the operation, the mice were fasted, and the mice were anesthetized with 3% chloral hydrate. After dehairing, the abdomen of the mice was cut open, the left ureter was found, and the lower end of the kidney was ligated, and a section behind the ligation point was The distance was ligated again, then the ureters in these two ligatures were cut, and the abdominal cavity was sutured.

[0019] The sham operation group only stripped the ureter without other operations.

[0020] Administration: After the operation, the ...

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Abstract

The invention relates to an application of (+)-guaiacylglycerol-beta-ferulic acid ether in preparation of a medicine for treating CKD. Results of the inventor show that the (+)-guaiacylglycerol-beta-ferulic acid ether has a relatively good treatment effect on a mouse model with unilateral ureteral obstruction, and the (+)-guaiacylglycerol-beta-ferulic acid ether can provide a new candidate medicine for treating chronic kidney diseases for clinic.

Description

technical field [0001] The present invention relates to the new application of (+)-guaiacylglycerol-β-ferulic acid ether, in particular to the use of (+)-guaiacylglycerol-β-ferulic acid ether for the treatment of chronic kidney disease renal fibrosis application of drugs. Background technique [0002] (+)-Guaiacylglycerol-β-ferulic acid ether is the chemical constituent of mangrove white bone soil, pomegranate, cactus and so on. (+)-Guaiacylglycerol-β-ferulic acid ether is a colorless oil, 1 HNMR (methanol, 800MHz) δ: 7.53 (d, J=15.9Hz, 1H), 7.09 (s, 1H), 7.01 (d, J=8.3Hz, 1H), 6.99 (d, J=1.8Hz, 1H) ,6.91(d,J=8.4Hz,1H),6.81(dd,J=8.1,1.8Hz,1H),6.68(d,J=8.1Hz,1H),6.29(d,J=15.9Hz,1H) ,4.78(d,J=5.9Hz,1H),4.46(td,J=5.8,3.9Hz,1H),3.80(dd,J=16.3,4.7Hz,2H),3.77(s,3H),3.75( s, 3H); 13 CNMR(MeOD, 201MHz)δ: 133.9(C-1), 111.9(C-2), 148.6(C-3), 147.0(C-4), 115.6(C-5), 121.0(C-6), 74.0(C-7), 85.4(C-8), 62.3(C-9), 129.6(C-1'), 112.3(C-2'), 151.5(C-3'), 151.7(C-4 '), 117.5(C-5'), 123...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/192A61P13/12
CPCA61K31/192A61P13/12
Inventor 赵英永苗华
Owner NORTHWEST UNIV