Application of lactobacillus acidophilus in preparation of food or medicine for preventing or treating antibiotic-associated diarrhea

A technology of Lactobacillus acidophilus and antibiotics, applied in the field of microorganisms, can solve limited problems, achieve the effect of alleviating antibiotic-associated diarrhea, reducing disease activity index, and improving the lesions of antibiotic-associated diarrhea

Pending Publication Date: 2022-07-15
JIANGSU WECARE BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, the probiotic products that can prevent or treat antibiotic-associated diarrhea in the prior art are still very limited, so it is very important to develop more probiotic products to improve antibiotic-associated diarrhea

Method used

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  • Application of lactobacillus acidophilus in preparation of food or medicine for preventing or treating antibiotic-associated diarrhea
  • Application of lactobacillus acidophilus in preparation of food or medicine for preventing or treating antibiotic-associated diarrhea
  • Application of lactobacillus acidophilus in preparation of food or medicine for preventing or treating antibiotic-associated diarrhea

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] The present embodiment provides a Lactobacillus acidophilus LA85 freeze-dried powder, and its preparation method is as follows:

[0049] The Lactobacillus acidophilus LA85 strain was inoculated into the medium according to the inoculum amount of 3% of the total mass of the MRS medium, and cultured at 37 ° C for 18 hours to obtain a culture solution; the culture solution was centrifuged to obtain the bacteria; the bacteria were used seaweed Sugar freeze-drying protective agent (containing trehalose 100g / L, skimmed milk powder 100g / L, solvent is water) is resuspended (the mass ratio of freeze-drying protective agent and thalline is 2:1) to obtain resuspended liquid; The liquid was freeze-dried by vacuum freezing method to obtain Lactobacillus acidophilus LA85 freeze-dried powder, and the number of viable bacteria was detected as 300 billion CFU / g.

Embodiment 2

[0072] The present embodiment provides a solid beverage with the efficacy of relieving antibiotic-related diarrhea, and its preparation method is as follows:

[0073] Mix 0.1 g of Lactobacillus acidophilus freeze-dried powder prepared in Example 1 with 1.9 g of inulin to homogenize, and the number of viable bacteria detected is 1 billion CFU / g.

Embodiment 3

[0075] The present embodiment provides a solid beverage with the efficacy of relieving antibiotic-related diarrhea, and its preparation method is as follows:

[0076] Mix 0.1 g of Lactobacillus acidophilus freeze-dried powder prepared in Example 1 with 1.9 g of resistant dextrin to homogenize, and the number of viable bacteria detected is 1 billion CFU / g.

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Abstract

The invention relates to application of lactobacillus acidophilus in preparation of food or medicine for preventing or treating antibiotic-related diarrhea. The lactobacillus acidophilus is named as lactobacillus acidophilus LA85 strain, the preservation unit is China General Microbiological Culture Collection Center (CGMCC), the preservation time is July 20, 2020, the preservation number is CGMCC 1.12735, and the address is No.3, Yard 1, Beichen West Road, Chaoyang District, Beijing.

Description

technical field [0001] The invention belongs to the technical field of microorganisms, and relates to a new medicinal use of Lactobacillus acidophilus, in particular to the application of Lactobacillus acidophilus in preparing food or medicine for preventing or treating antibiotic-related diarrhea. Background technique [0002] Gut microbes play an important role in human physiological metabolism and disease avoidance. A large number of commensal bacteria colonize and multiply in the gastrointestinal tract, and have a crucial impact on maintaining optimal host physiological and biochemical metabolic processes. The microbiota protects the host from infection by directly defending against invading microorganisms or by coordinating appropriate immune responses. The composition and metabolic activities of the human gut microbiota are regulated by a number of external factors including diet and antibiotic treatment, which in turn affect the structure and health of the host gut mi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/135A23L2/39A61K35/747A61P1/12
CPCA23L33/135A23L2/39A61K35/747A61P1/12A23V2002/00A23V2400/113A23V2200/3204
Inventor 方曙光盖忠辉董瑶吴银琴朱建国陈珂可
Owner JIANGSU WECARE BIOTECHNOLOGY CO LTD
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