Preparation method of skin-core structure electrostatic spinning nanofiber

A nanofiber and electrospinning technology is applied in the field of preparation of skin-core structure electrospinning nanofibers, which can solve the problems of low content of nanofiber skin-core nanofibers, high precision, difficult cleaning and maintenance, etc. Simple, improved thermal performance, low cost effect

Pending Publication Date: 2022-07-15
JIAXING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Coaxial electrospinning requires a special spinning nozzle, which requires high precision and is difficult to clean and maintain
At the same time, the spinning process of coaxial electrospinning is affected by many factors, such as the strength of the applied electric field, the compatibility of the solvents in the inner and outer tubes, the difference in the viscosity and surface tension of the solutions in the inner and outer tubes, the diameter matching of the inner and outer tubes, and the It is often difficult to spin out skin-core nanofibers or the content of skin-core nanofibers in the fiber membrane is not high.

Method used

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  • Preparation method of skin-core structure electrostatic spinning nanofiber
  • Preparation method of skin-core structure electrostatic spinning nanofiber
  • Preparation method of skin-core structure electrostatic spinning nanofiber

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Experimental program
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Effect test

Embodiment 1

[0038] A preparation method of a skin-core structure electrospinning nanofiber, the specific preparation steps are as follows:

[0039] (1) prepare organic montmorillonite, and the concrete preparation process is as follows:

[0040] (1.1) 10 g of sodium-based montmorillonite was added to 200 mL of deionized water to obtain a montmorillonite dispersion;

[0041] (1.2) 7.2 g of tetradecyltributylphosphonium bromide was added to the montmorillonite dispersion obtained in step (1.1), and the reaction was stirred at 40° C. for 8 hours, followed by centrifugation and 50% ethanol. The aqueous solution is washed, freeze-dried, and ground through a 200-mesh sieve to obtain organic montmorillonite;

[0042] (2) Add 0.016 g of the organic montmorillonite prepared in the above steps and 0.8 g of polylactic acid into 10 mL of hexafluoroisopropanol, stir at room temperature for 12 hours to obtain a mixed solution, and prepare a skin-core structure electrospun nanometer by electrospinning ...

Embodiment 2

[0052] A preparation method of a skin-core structure electrospinning nanofiber, the specific preparation steps are as follows:

[0053] (1) prepare organic montmorillonite, and the concrete preparation process is as follows:

[0054] (1.1) 10 g of calcium-based montmorillonite was added to 200 mL of deionized water to obtain a montmorillonite dispersion;

[0055] (1.2) 7.1 g of tetradecyltrimethylphosphonium bromide was added to the montmorillonite dispersion obtained in step (1.1), and the reaction was stirred at 25° C. for 12 hours, and then centrifuged in turn, mixed with 50% ethanol The aqueous solution is washed, freeze-dried, and ground through a 200-mesh sieve to obtain organic montmorillonite;

[0056] (2) Add 0.0012 g of the organic montmorillonite obtained in the above steps and 1.2 g of collagen into 10 mL of hexafluoroisopropanol, stir at room temperature for 12 hours to obtain a mixed solution, and prepare the skin-core structure electrospun nanometers by electro...

Embodiment 3

[0059] A preparation method of a skin-core structure electrospinning nanofiber, the specific preparation steps are as follows:

[0060] (1) prepare organic montmorillonite, and the concrete preparation process is as follows:

[0061] (1.1) 10g lithium-based montmorillonite was added to 150mL of deionized water to obtain a montmorillonite dispersion;

[0062] (1.2) 7.7g of cetylpyridinium bromide was added to the montmorillonite dispersion obtained in step (1.1), and the reaction was stirred at 80°C for 4h, followed by centrifugation, washing with 50% ethanol aqueous solution, Freeze-dry, grind and pass through a 200-mesh sieve to obtain organic montmorillonite;

[0063] (2) Add 0.08 g of the organic montmorillonite prepared in the above steps and 0.8 g of polycaprolactone into 10 mL of hexafluoroisopropanol, stir at room temperature for 12 hours to obtain a mixed solution, and prepare the skin-core structure electrostatically by electrospinning Spinning nanofibers; the spinn...

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Abstract

The invention relates to a preparation method of skin-core structure electrostatic spinning nanofibers, which comprises the following steps: firstly, carrying out ion exchange reaction on organic cations and montmorillonite to obtain organic montmorillonite, then adding the organic montmorillonite and a polymer into hexafluoroisopropanol, and uniformly mixing to obtain a mixed solution; the skin-core structure electrostatic spinning nanofiber is prepared through blending electrostatic spinning; the skin layer of the prepared skin-core structure electrostatic spinning nanofiber is a polymer, and the core layer is organic montmorillonite; the organic montmorillonite is composed of montmorillonite and organic cations distributed among montmorillonite layers. The fiber with the skin-core structure and the nano structure is prepared by adopting a blending electrostatic spinning method, the preparation method is simple to operate and low in cost, and good economic benefits can be brought; and the drug can be loaded between layers of the core layer organic montmorillonite to obtain the nanofiber with a three-layer structure, so that the multi-stage release of the drug is realized.

Description

technical field [0001] The invention belongs to the technical field of electrospinning nanofiber materials, and relates to a preparation method of a skin-core structure electrospinning nanofiber. Background technique [0002] Electrospun nanofiber membranes have shown very important application value in many fields such as biomedicine, filtration, catalysis, energy, etc. due to their excellent characteristics such as high specific surface area, high porosity and excellent mechanical properties. Compared with ordinary nanofibers In terms of skin-core nanofibers, they have greater advantages in various fields such as drug controlled release carriers, tissue regeneration, nanosensors, catalysis, batteries, etc., and have broad application value and huge market potential. wide attention from industry. At present, the preparation of skin-core nanofibers is mainly through coaxial electrospinning and emulsion electrospinning. Coaxial electrospinning requires special spinnerets, r...

Claims

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Application Information

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IPC IPC(8): D01F8/02D01F8/14D01F8/16D01F8/12D01F8/18D01D5/00D01D5/34A61K9/70A61K47/02A61K47/34A61K47/42A61K47/24A61K47/22A61K47/18
CPCD01F8/02D01F8/14D01F8/16D01F8/12D01F8/18D01D5/003D01D5/34A61K9/70A61K47/02A61K47/34A61K47/42A61K47/24A61K47/22A61K47/186
Inventor 周俊龙张葵花颜志勇程若冰樊勇勇尹岸林李喆
Owner JIAXING UNIV
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