Newborn individualized fluconazole administration amount calculation method and administration scheme recommendation system

Abstract

The invention provides a neonatal individualized fluconazole administration amount calculation method and an administration scheme recommendation system, and belongs to the technical field of intelligent medical information processing. The method comprises the following steps: inputting the gestational age of a neonatal patient and the body weight of the patient into a neonatal fluconazole population pharmacokinetic model to obtain initial values V1 and CL1 of individual neonatal pharmacokinetic parameters; adopting a Bayesian maximum posterior probability method to predict the blood concentration of fluconazole at the t moment after administration to the patient according to V1 and CL1; fitting the blood concentration at each time point, calculating the area AUC0-24 under the curve at the time of 0-24 hours, and evaluating the anti-infection curative effect; if the curative effect evaluation is reasonable, adopting the administration amount and the administration interval as an administration scheme; if the curative effect evaluation is not good, optimizing the administration scheme. According to the method, the pharmacokinetic model of the fluconazole is established by taking the Chinese neonates as samples, the pharmacokinetic characteristics of the Chinese neonates are better met, a scientific basis can be provided for clinical fluconazole medication of the Chinese neonates, and the medication safety and the curative effect are improved.

Description

technical field [0001] The invention relates to the technical field of intelligent medical information processing, in particular to a method for calculating the dosage of individualized fluconazole for newborns and a system for recommending a dosage regimen. Background technique [0002] Neonates, especially premature infants, often require repeated invasive operations such as broad-spectrum antibiotics, hormones, mechanical ventilation, peripheral intravenous nutrition, and central venous catheterization for a long time due to immature gastrointestinal tract development and low immune function. There is a higher risk of fungal growth and infection. Deep fungal infection has become the third most common cause of nosocomial infection in the neonatal intensive care unit (NICU). According to reports, the rate of invasive fungal infection in neonates is 6.9% to 9.0%, the fatality rate is as high as 23% to 32%, and the incidence of sequelae is 20 to 57%. It is difficult to dist...

AI Technical Summary

Problems solved by technology

At present, the dosage, frequency, route of administration, course of treatment, target population, and drug safety of fluconazole in the prophylactic treatment of fungal infections are still controversial, and long-term and extensive use may cause adverse drug reactions and side effects. Frequency of repeated irritation can lead to increase in fungal drug-resistant strains

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