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Drug absorption rate constant prediction model, device and storage medium

A prediction model and absorption rate technology, which is applied in the field of equipment and storage media, and the prediction model of drug absorption rate constant, can solve the problems that Loo-Riegelman cannot be applied, lack of drug intravenous data, etc., and achieve a wide range of applications, high accuracy, Accurately Predicted Effects

Pending Publication Date: 2022-07-29
HUNAN HUIZE BIO PHARMA CO LTD
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Problems solved by technology

Estimation of k by the Wagner-Nelson and Loo-Riegelman methods for a drug-time curve of a given drug formulation a The accuracy of the method is significantly higher than that of the non-compartmental model method, but the parameters of the compartmental model need to be accurately analyzed, and the lack of intravenous data of various drugs makes Loo-Riegelman unable to be applied, etc.

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  • Drug absorption rate constant prediction model, device and storage medium
  • Drug absorption rate constant prediction model, device and storage medium
  • Drug absorption rate constant prediction model, device and storage medium

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Embodiment

[0078] 1 Establishment of an absorption kinetics model that does not depend on the compartmental model for the in vivo absorption kinetics of pharmaceutical preparations

[0079] Medications in single dosesX 0 After administration, the total amount of drug that reaches the absorption site is X a . In the single-compartment model, the drug is absorbed as a first-order rate process (k a ), the dose of the drug entering the human body is X, and then it is eliminated in a first-order rate process (k); in the dual-compartment model, the drug is absorbed into the central compartment (blood) and distributed to the peripheral compartments (organs, tissues) in a first-order rate process. (k 12 ) and eliminate (k 10 ), the peripheral compartment drug also returns to the central compartment with a first-order rate process (k 21 ). Regardless of the single-compartment model and the two-compartment model drug, the drug-time curve is determined by T max It can be divided into absorpt...

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Abstract

The invention discloses a drug absorption rate constant prediction model, a device and a storage medium, an estimated ka value is obtained by building an absorption kinetic model independent of an atrioventricular model, a real ka value is obtained according to the existing atrioventricular model, the comparison difference is verified through the estimated ka value and the real ka value, and the drug absorption rate constant is predicted. The accuracy of the ka value is further verified on the basis of pharmacokinetic parameters, the ka value predicted by the prediction model is high in accuracy, venous blood concentration data is not needed, the requirement for drug absorption rate constant ka value estimation of different types of drugs can be met, and then an important tool is provided for in-vivo absorption kinetics analysis of a drug preparation and in-vivo evaluation of IVIVC of the drug preparation.

Description

technical field [0001] The invention relates to the technical field of drug information, in particular to a prediction model, equipment and storage medium of a drug absorption rate constant. Background technique [0002] Drug absorption refers to the process of drug uptake from the site of administration into the blood circulation. The rate of absorption of a drug is an important parameter in pharmacokinetic and bioavailability studies. The rate of absorption has a large effect on the plasma concentration, which is influenced by the route of administration and many other factors. Different routes of administration have different absorption rates; different dosage forms have different absorption rates. For example, the oral absorption of solid dosage forms depends on the disintegration of the preparation, the dissolution of the active drug, the drug concentration and blood circulation at the absorption site, and the location and area of ​​the absorption surface. If the dru...

Claims

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Application Information

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IPC IPC(8): G16H70/40G16C20/50G06F17/11
CPCG16H70/40G16C20/50G06F17/11
Inventor 冀闪贺劲杰
Owner HUNAN HUIZE BIO PHARMA CO LTD