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Method for judging acute inhalation toxicity of acute inhalation toxicity mixture in different states

A technology for inhalation toxicity and determination method, applied in the field of hazardous chemicals, can solve the problem of difficult data acquisition and achieve the effect of protecting animal welfare

Pending Publication Date: 2022-08-02
CHINA PETROLEUM & CHEM CORP +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For mixtures, the preferred acute toxicity classification method is to have overall classification data, but due to the variability of composition and content of substances in mixtures, overall data is not easy to obtain unless animal experiments are carried out

Method used

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  • Method for judging acute inhalation toxicity of acute inhalation toxicity mixture in different states
  • Method for judging acute inhalation toxicity of acute inhalation toxicity mixture in different states
  • Method for judging acute inhalation toxicity of acute inhalation toxicity mixture in different states

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] A chemical A, containing 1.9% nicotine, 6% diacetyl, 65% propylene glycol, and 27.1% glycerol, the acute toxicity of the contained chemicals is shown in Table 2 below:

[0053] Table 2

[0054]

[0055] According to the queried acute inhalation toxicity data, nicotine and diacetyl have acute inhalation toxicity, of which nicotine is the most harmful and is classified as acute toxicity-inhalation category 2. Since the acute inhalation toxicity data queried for diacetyl is an interval range, from From the perspective of strict classification, the acute toxicity data of diacetyl in the following acute calculation is 2.25mg / L.

[0056] The overall acute inhalation toxicity of this chemical A cannot be classified as Category 1, so the calculation starts with the classification of Category 2:

[0057] Category 2:

[0058] Since the nicotine and diacetyl acute toxicity data queried are values ​​in aerosol and vapor state respectively, the upper limit of classification cor...

Embodiment 2

[0068] A chemical B, containing dioctadecyl dimethyl ammonium chloride 25%, butyl glycol ether 6%, furfural 5%, glutaraldehyde 3%, water 61%, the acute toxicity of the contained chemical substances is detailed See Table 3 below:

[0069] table 3

[0070]

[0071] The acute inhalation toxicity value of ethylene glycol butyl ether is found to be 450ppm, which is less than 90% of its saturated vapor pressure of 1158ppm, so it is considered that 450ppm is the test data in the gas state. Dioctadecyl dimethyl ammonium chloride exceeds the classification critical value according to the queried data, it is considered that it does not have inhalation toxicity, and it is not considered in the classification calculation.

[0072] According to the acute inhalation toxicity data inquired, butyl glycol ether, furfural and glutaraldehyde have acute inhalation toxicity, all of which are acute toxicity inhalation category 2. Therefore, the acute inhalation toxicity of the overall mixture d...

Embodiment 3

[0083] A certain chemical C, containing isophorone diisocyanate 15%, ethylene glycol butyl ether 10%, urethane modified isocyanate 30%, ethyl acetate 45%, the acute toxicity of the contained chemicals is shown in Table 4 :

[0084] Table 4

[0085]

[0086] The acute inhalation toxicity value of ethylene glycol butyl ether is found to be 450ppm, which is less than 90% of its saturated vapor pressure of 1158ppm, so it is considered that 450ppm is the test data in the gas state. According to the acute inhalation toxicity data inquired, the acute inhalation toxicity of isophorone diisocyanate and ethylene glycol butyl ether is acute toxicity inhalation category 2, and the acute inhalation toxicity of ethyl acetate is category 4. Therefore, the acute inhalation toxicity of the overall mixture is Toxicity does not consider category 1, but starts from category 2:

[0087] Since the acute inhalation toxicity data of isophorone diisocyanate, ethylene glycol butyl ether and ethyl ac...

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Abstract

The invention discloses a method for judging acute inhalation toxicity of acute inhalation toxicity mixtures in different states, and belongs to the technical field of dangerous chemicals. According to the method, acute toxicity score values of different types of acute inhalation toxicity are calculated through a calculation formula of the method by utilizing a queried acute inhalation toxicity value and an acute toxicity classification critical value, and when the obtained acute toxicity score value is greater than 1, the category to which the mixture belongs is judged according to the strictest classification condition. The method provided by the invention solves the problem that known data cannot be effectively utilized to carry out overall acute inhalation toxicity classification on the mixture due to inconsistent inhalation states during data test of acute inhalation toxicity data of each substance of the known mixture. The method for judging the acute inhalation toxicity of the acute inhalation toxicity mixture in different states can be popularized and used, animal welfare is protected, and existing data are fully utilized.

Description

technical field [0001] The invention belongs to the technical field of hazardous chemicals, and relates to a method for calculating the acute inhalation toxicity of an overall mixture by the acute inhalation toxicity of each substance in the mixture, in particular to a method for determining the acute inhalation toxicity of acute inhalation toxicity mixtures in different states. Background technique [0002] The hazards of hazardous chemicals in my country include 16 categories of physical hazards, 10 categories of health hazards, and 2 categories of environmental hazards, with a total of 28 categories of hazards. Acute toxicity is one of the health hazards. Acute toxicity refers to the serious adverse health effects (ie lethality) of a substance or mixture after a single or brief oral, dermal or inhalation exposure. According to GB30000.18-2013 "Standards for Classification and Labeling of Chemicals - Part 18 Acute Toxicity", it is divided into five hazard categories accord...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G06K9/62
CPCG06F18/241
Inventor 王亚琴张金梅高月金满平张会光
Owner CHINA PETROLEUM & CHEM CORP
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