Flexible implantable platinum alloy array type sensor

A sensor and platinum alloy technology, applied in the field of medical equipment, can solve the problems of limited use scenarios of POCT products, difficulty in changing patient indicators, inconvenient to carry around, etc., achieve continuous real-time detection, mature formula, and be conducive to industrial production.

Pending Publication Date: 2022-08-05
JIANGSU PROVINCE HOSPITAL THE FIRST AFFILIATED HOSPITAL WITH NANJING MEDICAL UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] However, the current POCT products on the market are relatively large in size, making it inconvenient to carry them with you.
Moreover, blood samples are required for all operations, which limits the usage scenarios of POCT products
Although many POCT products are suitable for clinical detection, it is difficult to continuously reflect the real-time index changes of patients

Method used

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  • Flexible implantable platinum alloy array type sensor
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  • Flexible implantable platinum alloy array type sensor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1: The sensor of the present invention measures pH and pO2 in a sample

[0025] The platinum alloy array type sensor of the present invention can be used as a single sensor. A platinum-iridium alloy electrode is preferred, and a platinum-iridium alloy electrode is used in Embodiment 1 to measure the pH value or pO2 partial pressure in a biological sample. The sensor in this example does not require additional modification on the electrode surface, and only requires simple cleaning.

[0026] Experimental process: The method of pH measurement is: immerse the platinum alloy array sensor in buffer solutions of different pH values ​​at room temperature, and measure the potential value with a 6-channel EMF device. A double junction Ag / AgCl reference electrode (with 3M KCl inside and 1M lithium acetate outside) was used. The ionic activity coefficients used in the experimental data were calculated with reference to the Debye-Huckel equation, all potential values ​​we...

Embodiment 2

[0033] Example 2: The sensor of the present invention measures the concentration of ions, lactate or glucose in a sample

[0034] For platinum alloy array sensors, platinum-iridium alloy electrodes are preferred, and platinum-iridium alloy electrodes are used in Example 2. Platinum-iridium alloys can be used as electrode substrates, on which various sensing films can be modified to detect the content of substances in biological samples.

[0035] The sensor structure for this example includes:

[0036] The electrode substrate (1) and the sensing membrane layer (2) may include an ion-selective sensing membrane or an enzyme layer according to different samples to be detected.

[0037] The preparation method of the sensor of this embodiment is as follows:

[0038] Refer to patent CN109862830A or CN108593745A to configure enzyme solution or ion sensing membrane solution, and make liquid ion sensing membrane solution or enzyme solution form a film on the surface of platinum-iridiu...

Embodiment 3

[0050] Example 3: Determination of biochemical indicators in whole blood samples by the sensor of the present invention

[0051] The flexible implantable platinum alloy array sensor of this embodiment is suitable for the simultaneous and rapid determination of electrolytes, blood gases and metabolites in whole blood samples. The platinum alloy array sensor is composed of magnesium ion sensor, chloride ion sensor, sodium ion electrode, potassium ion electrode, calcium ion electrode, pH electrode, oxygen electrode, carbon dioxide electrode, blood sugar electrode, lactic acid electrode and reference electrode. A platinum alloy array type sensor is placed in a whole blood sample and the signal value is obtained. Using the linear correlation of different sensors respectively, the corresponding concentration value is obtained by calculating the signal value. The recovery was calculated with the theoretical value (NOVA analyzer). The results are shown in Table 8. The results show ...

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Abstract

The invention provides a flexible implantable platinum alloy array type sensor and application thereof in the technical field of medical equipment, the sensor takes a flexible platinum alloy as an electrode material, and the flexible implantable platinum alloy array type sensor can be directly used as a sensor or a substrate of the sensor; the contents of various ions, oxygen, carbon dioxide, respiratory metabolites such as pH value, glucose, lactic acid and other substances in a biological sample can be simultaneously detected. The device has the advantages of simple manufacturing process, high detection accuracy and the like.

Description

technical field [0001] The invention belongs to the technical field of medical equipment, and in particular, the invention relates to a flexible implantable platinum alloy array sensor and its application in the technical field of medical equipment. Background technique [0002] Point of Care testing (POCT), as one of the subdivisions of the in vitro diagnostic industry, has the advantages of instant and small size. With the promotion of hierarchical diagnosis and treatment, it has become a leading role in primary hospitals. While continuously guiding patients to seek medical treatment, it also continuously improves the medical treatment level and equipment configuration of primary hospitals, and promotes the miniaturization of products and instant detection. POCT has gradually opened up the market. [0003] Sodium is the most important cation in extracellular fluid, and it is of great significance for maintaining osmotic pressure, acid-base balance, water balance and regula...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/145G01N27/26G01N27/30G01N27/333
CPCA61B5/14503A61B5/14532A61B5/14539G01N27/26G01N27/30G01N27/3335
Inventor 周林福季子菡周俊宇秦玉
Owner JIANGSU PROVINCE HOSPITAL THE FIRST AFFILIATED HOSPITAL WITH NANJING MEDICAL UNIV
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