Application of tangerine seed extract in medicine for treating healthy aging

A technology of extract and orange core, applied in the field of natural medicinal chemistry, can solve the problems of no literature reporting CRS anti-aging application, etc., and achieve the effect of promoting clinical application, prolonging life, and promoting health.

Pending Publication Date: 2022-08-05
SOUTHWEST MEDICAL UNIVERISTY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, no literature has reported the application of CRS in anti-aging

Method used

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  • Application of tangerine seed extract in medicine for treating healthy aging
  • Application of tangerine seed extract in medicine for treating healthy aging
  • Application of tangerine seed extract in medicine for treating healthy aging

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] 1. Material Preparation

[0030] Pulverize the dried orange pips with a pulverizer, add 75% ethanol and let stand overnight, filter with a multi-circulating suction filter, retain the liquid to obtain an extract, pour the extract into a crucible and place it in a 90°C water bath for volatilization. Dry, remove the ethanol in the extract, and obtain the dried crude extract of orange pip, namely citrus pip extract.

[0031] 2. Materials and methods

[0032] 2.1 Caenorhabditis elegans: species, culture and synchronization

[0033] The following C. elegans species were used in this study:

[0034] Bristol N2 (wild type), SJ4005 zcIs4[hsp-4::GFP]V, SJ4100 zcIs13[hsp-6::GFP], CF15 53muIs84[(pAD76)sod-3p::GFP+rol-6(su1006)] , CL2166 dvIs19[(pAF15)gst-4p::GFP::NLS]III, NL5901 pkIs2386[unc-54p. :alphasynuclein::YFP+unc-119(+)],BZ555 egIs1[dat-1p::GFP],AM141 rmIs133[unc-54p::Q40::YFP],DA2123adIs2122[lgg-1p::GFP::l gg-1+rol-6(su1006)] and BC12921 sIs10729[rCes T12G3.1::GFP+pC...

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Abstract

The invention relates to the field of medicinal chemistry, in particular to application of a tangerine seed extract in a medicine for treating healthy aging, and the tangerine seed extract is a tangerine seed ethanol extract. It is reported that the tangerine seed extract serves as a potential candidate drug for promoting longevity, the tangerine seed extract prolongs the life of caenorhabditis elegans by activating the autophagy effect, health is promoted, and the tangerine seed extract has a quite large treatment effect on senescence and senescence-related diseases; the clinical application of the tangerine seed extract in senescence and senescence-related diseases can be better promoted.

Description

technical field [0001] The invention relates to the field of natural medicinal chemistry, in particular to the application of citrus seed extract in medicine for treating healthy aging. Background technique [0002] Aging is a complex biological process in which cellular structure and function gradually deteriorate over time. Aging leads to a decrease in quality of life and an increased likelihood of death; at the same time, aging is one of the major risk factors for the development of many diseases, especially neurodegenerative diseases (NDS) , such as Alzheimer's disease (AD), Parkinson's disease (PD) and Huntington's disease (HD). The global population over the age of 65 is currently growing at an unprecedented rate and is expected to reach 1.6 billion by 2050. Most older adults are affected by multiple chronic diseases that lead to an increased risk of physical and cognitive disability. Collectively, aging and its associated diseases represent a major medical and socio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/752A61P39/06A61K131/00
CPCA61K36/752A61P39/06A61K2236/333A61K2236/51
Inventor 周晓钢吴安国秦大莲吴建明龙涛何长龙唐勇
Owner SOUTHWEST MEDICAL UNIVERISTY
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