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Application of electrical stimulation in regulation and control of MDK in living body

An electrical stimulation, biological technology, applied in the field of biotechnology and medicine, can solve problems such as disturbing the cell cycle

Pending Publication Date: 2022-08-05
JIANGSU PROVINCE HOSPITAL THE FIRST AFFILIATED HOSPITAL WITH NANJING MEDICAL UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] No technical means to regulate MDK expression has been found in the prior art, and only one article proposed that low-frequency magnetic fields can inhibit tumor cell proliferation and interfere with cell cycle by transplanting MDK expression 3

Method used

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  • Application of electrical stimulation in regulation and control of MDK in living body
  • Application of electrical stimulation in regulation and control of MDK in living body
  • Application of electrical stimulation in regulation and control of MDK in living body

Examples

Experimental program
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Effect test

Embodiment 1

[0035] 1. Experimental materials and methods

[0036] 1. Experimental materials

[0037] 1.1 Experimental animals and cells

[0038] Adult male SPF grade ICR mice: 20-22g, 8 weeks old, provided by Shanghai Sipple-Bikai Laboratory Animal Co., Ltd., experimental animal license number: SCXK (Shanghai) 2018-0006.

[0039] All animal experiments were carried out in strict accordance with the regulations of the Ethics Committee of the International Association for the Study of Pain and the Guidelines for the Care and Use of Laboratory Animals (Ministry of Science and Technology of China, 2006). All animal experiments were approved by the Animal Care and Use Committee of Nanjing Medical University and are designed to minimize animal distress and use.

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PUM

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Abstract

The invention discloses the application of electrical stimulation in regulation and control of MDK in a living body for the first time, the electrical stimulation can improve MDK in plasma or muscle, and exogenous MDK does not need to be added as supplement. The method can be used for further laying a foundation for research on MDK-related diseases and drugs, such as prevention, treatment and research on neurons, tissue repair, immune diseases and the like.

Description

technical field [0001] The invention relates to a biological regulation method, in particular to the application of electrical stimulation in regulating MDK in vivo, and belongs to the fields of biotechnology and medical technology. Background technique [0002] Midkine (Chinese: Midkine, English abbreviation MDK) is a secreted heparin-binding growth factor, a low molecular weight protein. Midkine plays an important role during development and is strongly expressed in the second trimester. In adults, its expression is restricted to certain tissues. Midkine promotes cell survival and migration and is deeply involved in cancer progression, inflammatory disease development and repair of damaged tissue. [0003] MDK has a variety of activities in vitro, which are mainly divided into the following three categories: ① neurotrophic activity, promoting the survival of neurons; ② promoting the expression of cytokines in renal epithelial cells and bone marrow cells; ③ promoting embr...

Claims

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Application Information

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IPC IPC(8): A61N1/36C12N5/077C12N5/0786G01N33/68
CPCA61N1/36014C12N5/0658C12N5/0645G01N33/6863C12N2529/00G01N2333/475Y02A50/30
Inventor 沈滢刘文涛王海涛胡亮宗丽娟林彤彤
Owner JIANGSU PROVINCE HOSPITAL THE FIRST AFFILIATED HOSPITAL WITH NANJING MEDICAL UNIV
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