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Method for constructing machine learning model for identifying infectious diseases and non-infectious diseases

A machine learning model, a technology for infectious diseases, applied in the field of medical diagnosis, which can solve problems to be studied, etc.

Pending Publication Date: 2022-08-05
BGI GENOMICS CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Therefore, methods to identify infectious and non-infectious diseases remain to be investigated

Method used

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  • Method for constructing machine learning model for identifying infectious diseases and non-infectious diseases
  • Method for constructing machine learning model for identifying infectious diseases and non-infectious diseases
  • Method for constructing machine learning model for identifying infectious diseases and non-infectious diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0087] Example 1 Identification of infectious and non-infectious encephalitis

[0088] 1. Sample entry and clinical differential diagnosis:

[0089] The full name of autoimmune encephalitis is autoimmune encephalitis, which is an inflammation mediated by immune mechanisms, mostly involving the white matter of the brain and manifesting as demyelination of the white matter. Most autoimmune brains are caused by viral infections or tumors. The diagnosis of autoimmune brain includes four aspects: clinical manifestations, auxiliary examinations, confirmatory experiments and exclusion of other causes. Diagnosed autoimmune encephalitis (Autoimmune Encephalitis, AE): meet the following diagnostic conditions 1 to 4. The diagnosis of AE requires a combination of the patient's clinical manifestations, cerebrospinal fluid examination, neuroimaging, and electroencephalographic examination results. The positive anti-neuron antibody is the main basis for the diagnosis.

[0090] 1.1 Clinica...

Embodiment 2

[0112] Example 2 Identification of infectious and non-infectious pneumonia

[0113] 1. Sample entry and clinical differential diagnosis:

[0114] The infectious pneumonia samples in this example are all samples of community-acquired pneumonia.

[0115] Community-acquired pneumonia is caused by a variety of microorganisms such as bacteria, viruses, chlamydia, and mycoplasma only outside the hospital. The main clinical symptoms are cough, with or without expectoration and chest pain, and the prodromal symptoms are mainly rhinitis-like symptoms or symptoms of upper respiratory tract infection, such as nasal congestion, runny nose, sneezing, dry throat, sore throat, foreign body sensation in the pharynx , Hoarseness, headache, dizziness, hot eyes, tearing and mild cough. Not every patient with community-acquired pneumonia will have prodromal symptoms, and the incidence is generally between 30% and 65% depending on the pathogen.

[0116] The diagnosis of community-acquired pneum...

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Abstract

The invention provides a method for constructing a machine learning model for identifying infectious diseases and non-infectious diseases. The method comprises the following steps: respectively measuring host gene expression quantity values and / or microorganism relative abundance values in biological samples of known subjects suffering from infectious diseases and known subjects suffering from non-infectious diseases; and respectively inputting the host gene expression quantity value and / or the microorganism relative abundance value into a trainer, and training by taking the infectious diseases and the non-infectious diseases as markers so as to obtain a machine learning model for identifying the infectious diseases and the non-infectious diseases. The machine learning model can be used for accurately identifying infectious diseases and non-infectious diseases, and has important scientific research and clinical diagnosis values.

Description

technical field [0001] The present invention relates to the field of medical diagnosis. In particular, the present invention relates to methods of constructing machine learning models for the identification of infectious and non-infectious diseases. Background technique [0002] Infectious diseases refer to the invasive diseases of pathogens, the proliferation of pathogens and the response of host tissues to pathogens and their toxins, which are diseases caused by infection. Non-infectious diseases refer to diseases that are not caused by pathogen infection, but can also lead to the activation of the body's immune system, such as cancer, Alzheimer's disease and epilepsy. Differential diagnosis of respiratory infectious diseases (such as pneumonia), central nervous system infectious diseases (such as encephalitis and meningitis) and non-infectious diseases, especially systemic bacterial infections in the intensive care unit . The clinical symptoms are atypical, the progres...

Claims

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Application Information

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IPC IPC(8): C12Q1/6883C12Q1/689C12Q1/6895G16B25/10G16B30/00G16B40/00
CPCC12Q1/6883C12Q1/689C12Q1/6895G16B25/10G16B30/00G16B40/00C12Q2600/158Y02A90/10Y02A50/30
Inventor 祝中一麻锦敏陈唯军
Owner BGI GENOMICS CO LTD