Methods for hypoxic blood storage and pathogen inactivation
A pathogen and blood technology, applied in the field of hypoxic blood storage and pathogen inactivation, can solve problems such as shortening and reduction in red blood cell quality
Pending Publication Date: 2022-08-05
HEMANEXT INC
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Problems solved by technology
However, recent studies have shown that RBCs obtained from whole blood irradiated using riboflavin / ultraviolet technology (Mirasol, TerumoBCT) are of significantly lower quality compared to untreated study groups, if shelf life under standard storage conditions requires shortened words
Method used
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Embodiment 1
[0126] Embodiment 1. A method for reducing blood pathogens with reduced hemolysis, comprising:
[0127] The removal of oxygen from blood products to make oxygen-depleted blood products;
[0128] Reduction of blood pathogens from the blood product including:
[0129] Add riboflavin to a final concentration of 40 to 60 μM; and
[0130] The riboflavin-containing blood product is irradiated with UV light between 265-400 nm.
Embodiment 2
[0131] Embodiment 2. The method of Embodiment 1, further comprising storing the oxygen-reduced pathogen-reduced blood product under hypoxic conditions.
Embodiment 3
[0132] Embodiment 3. The method of Embodiment 1, further comprising reducing carbon dioxide from the blood product.
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The present disclosure relates to a method for reducing pathogens in a blood product comprising: i) removing oxygen from the blood product; ii) reducing blood pathogens t from the blood product: adding an amstamine (S-303) to a final concentration of 0.2 mmol (mM); and glutathione (GSH) to a concentration of 20 mM; iii) reducing S-303 to a concentration below 1 nmol / L, comprising incubating the oxygen reduced blood product under oxygen reduced conditions for up to 6 hours; and to a reduced pathogen, reduced oxygen blood product having an oxygen saturation (sO2) of less than 25%, a pCO2 of 90 mmHg or less at 37 DEG C, and a concentration of aminostatin (S-303) of less than 1 nmol / L.
Description
[0001] CROSS-REFERENCE TO RELATED APPLICATIONS [0002] This application claims priority to US Provisional Application No. 62 / 928,714, filed on October 31, 2019. The entire contents of this application are incorporated herein by reference. technical field [0003] The present disclosure relates to methods of improving the quality and safety of blood and blood products used in transfusion medicine. Background technique [0004] The use of blood and blood components for blood transfusion is a common practice in medicine today, but poses risks to patients due to potential exposure to immunogenic and pathogenic contaminants. This risk is exacerbated by the practice of storing collected blood and blood components for up to several weeks. Whole blood is typically processed by filtration to remove white blood cells (leukopenia) and then centrifuged to separate the 3 major blood components of plasma, platelets and red blood cells. The leukopenic packed red blood cells (LRpRBC) a...
Claims
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IPC IPC(8): A01N1/02
CPCA01N1/0215A01N1/0226
Inventor 杰弗里·萨顿吉田达郎塞缪尔·O·索韦米莫-科克尔
Owner HEMANEXT INC