8-quinoline sulfonamide compound and application thereof
A quinoline sulfonamide and compound technology, applied in the field of medicinal chemistry, can solve problems such as incomplete remission
Pending Publication Date: 2022-08-09
ANHUI RUBIOX VISION BIOTECH
0 Cites 0 Cited by
AI-Extracted Technical Summary
Problems solved by technology
View more
Abstract
The invention relates to an 8-quinoline sulfonamide compound and application thereof. R is hydrogen, 4-methyl, 4-isopropyl, 2, 4, 6-triisopropyl, 4-tert-butyl, 2, 4-dimethoxy, 3, 4-dimethoxy, 2-fluorine, 3-fluorine, 4-fluorine, 2, 6-difluorine, 2-trifluoromethyl, 3-trifluoromethyl, 4-trifluoromethyl, 3, 5-di-trifluoromethyl, 2-trifluoromethoxy, 4-trifluoromethoxy, 2-chlorine, 4-chlorine, 2, 6-dichloro, 3, 4-dimethoxy, 4-tert-butyl, 2, 4-dimethoxy, 3, 4-dimethoxy, 4-tert-butyl, 2, 4-dimethoxy, 3, 4-dimethoxy, 2-trifluoromethyl, 3, 5-di-trifluoromethyl, 2-trifluoromethoxy, 4-trifluoromethoxy, 2-chlorine, 4-chlorine, 2, 6-dichloro, 3, the compound is any one of 2, 5-dichloro, 2-bromo, 3-bromo, 4-bromo, 3-bromine-5-trifluoromethyl and the like. The compound has an inhibiting effect on generation of macrophage NO stimulated by LPS, can reduce release of inflammation-related cytokines and expression of protein, and has the potential to be developed into a medicine for treating inflammatory diseases.
Application Domain
Organic chemistryAntipyretic +4
Technology Topic
SulfonilamideTrifluoromethyl +10
Image
Examples
- Experimental program(35)
Example Embodiment
Example Embodiment
Example Embodiment
PUM


Description & Claims & Application Information
We can also present the details of the Description, Claims and Application information to help users get a comprehensive understanding of the technical details of the patent, such as background art, summary of invention, brief description of drawings, description of embodiments, and other original content. On the other hand, users can also determine the specific scope of protection of the technology through the list of claims; as well as understand the changes in the life cycle of the technology with the presentation of the patent timeline. Login to view more.