8-quinoline sulfonamide compound and application thereof
A quinoline sulfonamide and compound technology, applied in the field of medicinal chemistry, can solve problems such as incomplete remission
Pending Publication Date: 2022-08-09
ANHUI RUBIOX VISION BIOTECH
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Problems solved by technology
The invention relates to an 8-quinoline sulfonamide compound and application thereof. R is hydrogen, 4-methyl, 4-isopropyl, 2, 4, 6-triisopropyl, 4-tert-butyl, 2, 4-dimethoxy, 3, 4-dimethoxy, 2-fluorine, 3-fluorine, 4-fluorine, 2, 6-difluorine, 2-trifluoromethyl, 3-trifluoromethyl, 4-trifluoromethyl, 3, 5-di-trifluoromethyl, 2-trifluoromethoxy, 4-trifluoromethoxy, 2-chlorine, 4-chlorine, 2, 6-dichloro, 3, 4-dimethoxy, 4-tert-butyl, 2, 4-dimethoxy, 3, 4-dimethoxy, 4-tert-butyl, 2, 4-dimethoxy, 3, 4-dimethoxy, 2-trifluoromethyl, 3, 5-di-trifluoromethyl, 2-trifluoromethoxy, 4-trifluoromethoxy, 2-chlorine, 4-chlorine, 2, 6-dichloro, 3, the compound is any one of 2, 5-dichloro, 2-bromo, 3-bromo, 4-bromo, 3-bromine-5-trifluoromethyl and the like. The compound has an inhibiting effect on generation of macrophage NO stimulated by LPS, can reduce release of inflammation-related cytokines and expression of protein, and has the potential to be developed into a medicine for treating inflammatory diseases.
Organic chemistryAntipyretic +4
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