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Method for coating antibiotic onto articles with interlinked micro-cavities, products thereby and use thereof

An antibiotic and cavity technology, used in prostheses, coatings, bone implants, etc., can solve the problem of no one paying attention to the layering properties of water-slightly soluble antibiotic salts, and achieve the effect of low cost

Inactive Publication Date: 2005-04-20
HERAEUS KULZER GMBH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Likewise, so far no one has noticed the layer-forming properties of slightly water-soluble antibiotic salts based on organic sulfates and sulfonates

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0048] In Examples 1-8, square absorbable phosphate glass was used as the body with interconnected microporous system, dimensions: 20 x 20 x 10 mm. Their total porosity is 65% by volume.

[0049] The general preparatory work of example 1~5 products:

[0050] Dissolve 50-100 mg of gentamicin sulfate in 1 g of double distilled water (solution 1). In addition, 50-150 mg of sodium lauryl sulfate was dissolved in 1 g of water to form a solution (solution 2). The pre-prepared water-soluble gentamycin sulfate solution was first dropped into the microwells of the square phosphate glass. The sample object then sucks up the gentamicin sulfate solution. The water present in the micropores is then dried with anhydrous calcium chloride to remove it. Then, drop the prepared sodium lauryl sulfate solution into the micropores of the dried phosphate glass. Drying of the sample body was also carried out with anhydrous calcium chloride until it became a shaped body.

[0051] Table ...

Embodiment 6～8

[0065] The antibiotic release of embodiment 6~8 sample object:

[0066]The release of antibiotics is the same as in Examples 1-5, and the evaluation of gentamicin is also carried out in a similar microbial manner, using Bacillus subtilis ATCC 6633 as the test strain. The results of the release check are listed in Table 4. From these results, it can be seen that both the sample objects coated with the aqueous solution of gentamicin sulfate and the aqueous solution of sodium dodecylsulfate showed the ability to delay the release of gentamicin for a period of 28 days. After 28 days, the release test was stopped. The weight of the used gentamicin sulfate of antibiotic coating and the weight of the gentamicin that discharges compare and illustrate: the share that gentamicin accounts for in the coating after 28 days is still quite a lot. Example 8 clearly shows that the release of gentamicin during the first few days can be significantly reduced.

[0067] Table 4, the mic...

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PUM

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Abstract

The present invention relates to a method of coating an object with interconnected microcavities with antibiotics and the coated object and its use. The method of the present invention is characterized in that an aqueous solution 1 is introduced into the microcavity of a non-metallic object. The solution contains at least one water-soluble antibacterial component selected from the group consisting of aminoglycoside antibiotics, tetracycline antibiotics, and lincosamide antibiotics. and 4-quinolone antibiotics, and aqueous solution 2 is also introduced, which is at least one water-soluble amphiphilic molecular component selected from the group consisting of alkyl sulfates, alkyl sulfonates, alkyl aryl sulfates, dialkyl Aryl sulfates, alkylaryl sulfonates, dialkylaryl sulfonates, cycloalkyl sulfates, cycloalkyl sulfonates, alkylcycloalkyl sulfates, and after introducing solution 1 and solution 2, the water is basically removed through evaporation and / or volatilization, and thereby the components of solution 1 and solution 2 form a slightly water-soluble precipitate in the microcavity.

Description

technical field [0001] The present invention relates to a method for the antibiotic coating of objects having interconnected micro-cavities by treatment with a two-component system, the coated objects and their use. Background technique [0002] Skeletal defects are relatively common in human and veterinary medicine, especially those caused by bone fistulas, comminuted fractures, and tumors. Complicated infection of the bone tissue has been observed several times in open comminuted fractures. Bone defects are successfully treated with properly filled implants. In recent years, especially porous implants have attracted special interest, showing osteoinductive effects in terms of their chemical composition and their porous structure, thus favoring the growth of surrounding bone tissue. The problem is that the treatment of skeletal defects is often accompanied by microbial infection of the bone tissue. Infections of bone tissue can be prevented by systemic or topical adminis...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/54A61F2/28A61K9/00A61L27/00A61L27/28
CPCA61K9/0024A61P19/08A61P31/00A61P31/04
Inventor 塞巴斯蒂安·福哥特马蒂亚斯·斯纳波劳克劳斯-迪特尔·科恩
Owner HERAEUS KULZER GMBH