Immune regulatorand its use in producing medicine

An immunomodulator and a technology for immune diseases, applied to the immunomodulator and its application in pharmaceuticals, can solve problems such as loss of active components, waste of resources, etc., and achieve a simple and feasible preparation process, good economic value and environmental protection. Effect

Inactive Publication Date: 2005-09-21
JINLING PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the preparation process, after the medicinal materials are subjected to multi-step processes such as water extraction, alcohol precipitation, and ethyl acetate refining, other active ingredients with immune regulation effects are still lost, resulting in a large waste of resources

Method used

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  • Immune regulatorand its use in producing medicine
  • Immune regulatorand its use in producing medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Take 250g of Achyranthes bidentata, 250g of Scrophulariaceae, 250g of Dendrobium, 250g of honeysuckle, add 6 times the amount of water, soak for 1.5 hours, decoct and extract twice, each time for 1.5 hours, combine the extracts, filter, and concentrate under reduced pressure to 65°C The relative density is 1.30; cooling, add ethanol, make the alcohol content to 80%, let stand for 24 hours; take the supernatant, recover and remove ethanol, the relative density when concentrated under reduced pressure to 65 ℃ is 1.10; use 3 Double the amount of ethyl acetate for countercurrent extraction, the extract is used for other purposes, add 8 times the amount of water to the residue and boil for 3 hours, filter to obtain a water extract; when concentrated under reduced pressure to 65°C, the relative density is 1.30, and vacuum dried at 65°C ; Grinding to 80 mesh fine powder, adding soluble starch to make granules.

Embodiment 2

[0022] Add 425g of Achyranthes bidentata, 525g of Scrophulariaceae, 325g of Dendrobium, 425g of honeysuckle, add 6 times the amount of water, soak for 1.5 hours, decoct and extract twice, each time for 1 hour, combine the extracts, filter, and concentrate under reduced pressure to 65°C The relative density is 1.30; cool down, add ethanol to make the alcohol content to 80%, and let it stand for 24 hours; take the supernatant, recover and remove the ethanol, and concentrate under reduced pressure to 65 ° C. The relative density is 1.10; use 3 times Amount of ethyl acetate was countercurrently extracted, and the extract was used for other purposes. Add 10 times the amount of water to the residue and boil for 2 hours. After standing for 3 hours, filter and remove impurities, and concentrate under reduced pressure to 65 ° C. The relative density is 1.10. Add stevioside, Tween-80, adjust the pH value to 8.5, add water to 1000ml, then fill and sterilize to prepare oral liquid.

Embodiment 3

[0023] Embodiment 3: the influence of the present invention on mouse immune function

[0024] 1. Experimental materials:

[0025] 1. Biological Health Oral Liquid (product of Guangdong Taiyangshen Company).

[0026] 2. The present invention (prepared according to Example 2).

[0027] 3. Kunming mice, both male and female, weighing 18-22 grams, provided by the Experimental Animal Center of Nanjing Medical University.

[0028] 2. Experimental methods and results:

[0029] 1, the present invention is to the impact of mouse immune organ weight

[0030] Get 50 mice, both male and female, randomly divided into groups, 10 in every group, i.e. normal control group, biological health group, low, medium and high dose groups of the present invention, respectively fed with distilled water, biological health oral liquid, three doses of the present invention. Dosage, once a day, for 6 consecutive days, the mice were sacrificed on the 7th day, the spleen and thymus were weighed, and the ...

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Abstract

The present invention discloses immune regulator prepared with waste material of Mailuoning injection process and its application in producing medicine. The dregs after ethyl acetate extraction is water extracted, and the extractive is concentrated or dried and mixed with supplementary material to prepare the immune regulator. The immune regulator may be used in preparing medicine for preventing and treating immunological diseases. Utilizing the waste to prepare the immune regulator has high economic value and excellent environment protecting effect.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine pharmacy, and in particular relates to an immunomodulator prepared by using waste in the preparation process of Mailuoning injection and its application in pharmacy. Background technique [0002] Mailuoning injection is prepared from Achyranthes bidentata, Scrophulariaceae, Dendrobium and Honeysuckle. However, in the preparation process, after the medicinal materials are subjected to multi-step processes such as water extraction, alcohol precipitation, and ethyl acetate refining, other active ingredients with immunoregulatory effects are still lost, resulting in a large waste of resources. Contents of the invention [0003] The object of the present invention is to provide an immunomodulator, which is prepared by using the waste in the process of producing Mailuoning injection. [0004] Another object of the present invention is to provide the application of the above immunomodulator...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61P37/02
Inventor 王兴旺徐向阳孙晔张蕙张庆晓万辉张杰陈钟陈希倪洁夏云谢俊田丽娟张春来
Owner JINLING PHARMA
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