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Total gambogic acid preparation and its preparing method

A technology of gambogic acid and gambogic acid, which is applied in the field of preparations and its preparation, and total gambogic acid, which can solve problems such as poor stability and inconvenient clinical use

Inactive Publication Date: 2006-01-11
JIANGSU AOSAIKANG PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The gambogic acid extracted by the above method has anti-tumor effect, and it is also reported that the injection made of gambogic acid is used in anti-tumor research. The injections reported at present mainly have those directly dissolved in water and prepared with boric acid solution. These injections need A large amount of co-solvent is added, the stability is poor, and it is inconvenient to use clinically

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0294] Formula: 1000 bottles of freeze-dried injection, 25g total gambogic acid, 20g L-arginine, 40g mannitol, 2000ml water for injection.

[0295] Take the prescription amount of total gambogic acid and place it in a suitable container, add an appropriate amount of water for injection (80% of the total volume) and mix well, add L-arginine and dissolve it ultrasonically until it is clear, add mannitol, stir to dissolve, add 1% for injection Charcoal, stir for 30 minutes, decarbonize, add water for injection to a sufficient amount, after the determination of the intermediate content, filter under aseptic conditions with a 0.22 microporous membrane filter, and fill the filtrate in a 10ml vial, 2ml per bottle, half Stopper, load the plate, put it into the freeze-drying box, insert the temperature sensor, close the door and turn it on until it is dry, tightly stuffed, out of the box, tying the lid, checking, and packaging.

Embodiment 2

[0297] Formula: 1000 bottles of injection, 25g total gambogic acid, 20g L-arginine, 40g mannitol, 2000ml water for injection.

[0298] Take the prescription amount of total gambogic acid and place it in a suitable container, add an appropriate amount of water for injection (80% of the total volume) and mix well, add L-arginine and dissolve it ultrasonically until it is clear, add mannitol, stir to dissolve, add 1% for injection Stir for 30 minutes, decarbonize, add water for injection to a sufficient amount. After the intermediate content is determined to be qualified, filter with a 0.22 microporous membrane under aseptic conditions, and fill the filtrate into a 10ml vial of 2ml each.

Embodiment 3

[0300] Cut the gamboge resin into small particles, pulverize it into powder (about 10 mesh) with a pulverizer, put 600g of the gamboge powder into a 3000ml Erlenmeyer flask, add 1500ml pyridine, shake and stand for 30 minutes, then transfer it to a 85℃ water bath to heat Soak for 2 hours with constant shaking, filter while hot, wash the filter flask with hot pyridine 3 times, 100ml each time, combine the filtrate and washing liquid into 150ml hot water at 60°C, and place in the refrigerator overnight. Take it out the next day and filter under reduced pressure. The filter cake is washed twice with 70% pyridine, 80ml each time, and then washed three times with distilled water, 60ml each time. After draining, it is dried under infrared light to obtain 75g of dry product. The yield was 12.5%.

[0301] Put the above dry product into a 1000ml round bottom flask, add 600ml ether, reflux on a water bath to dissolve, let cool, filter out the insoluble matter, concentrate the filtrate to 1 / ...

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Abstract

The present invention provides a kind of new general gambogic acid preparation. The general gambogic acid preparation consists of general gambogic acid 12.5-37.5 wt%, L-arginine 10-30 wt% and mannitol 20-60 wt%. The present invention also includes the preparation process of the said preparation.

Description

Technical field: [0001] The invention relates to a traditional Chinese medicine preparation, in particular to total gambogic acid, a preparation containing it and a preparation method thereof. Background technique: [0002] Garcinia cambogia is a dry resin secreted by the Garcinia cambogia tree of the gamboge family. The product has been included in the United States Pharmacopoeia. Its active ingredients are mainly gambogic acid and other acidic effective parts, namely total gambogic acid. In 1955, Amorosa obtained pure gambogic acid for the first time by making pyridine salt crystals. In 1965, the molecular structure of gambogic acid was determined with the help of nuclear magnetic resonance. Later, the research work on gambogic acid continued to deepen. There are many reports on the preparation method of gambogic acid, including three. The first route is to soak the Garcinia Cambogia granules in acetone overnight, combine the acetone solution to obtain the acetone extract of Ga...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/35A61K36/185A61P35/00
Inventor 陈庆才赵俊
Owner JIANGSU AOSAIKANG PHARMA CO LTD
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