Total gambogic acid preparation and its preparing method

A technology of total gambogic acid and gambogic acid, which is applied in preparation and its preparation, and the field of total gambogic acid, which can solve the problems of poor stability and inconvenient clinical use, and achieve good anti-tumor effect

Inactive Publication Date: 2003-01-22
JIANGSU AOSAIKANG PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The gambogic acid extracted by the above method has anti-tumor effect, and it is also reported that the injection made of gambogic acid is used in anti-tumor research. The injections reported at present mainly have those directly dissolved in water and prepared with boric acid solution. These injections need A large amount of co-solvent is added, the stability is poor, and it is inconvenient to use clinically

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0362] Example 1 Formula: 1000 bottles of lyophilized injection, 25 g of total gambogic acid, 20 g of L-arginine, 40 g of mannitol, and 2000 ml of water for injection.

[0363] Take the prescribed amount of total gambogic acid, put it in a suitable container, add an appropriate amount of water for injection (80% of the total volume), stir well, add L-arginine to dissolve until clear, add mannitol, stir to dissolve, add 1% for injection Charcoal, stirred for 30 minutes, decarbonized, added water for injection to a sufficient amount, after the determination of the intermediate content was qualified, under sterile conditions, 0.22 microporous membrane filtration, the filtrate was filled in 10ml vials, 2ml per bottle, half Stoppering, loading into trays, putting into the freeze-drying box, inserting the temperature sensor, closing the box door, turning on the machine and drying it, sealing it tightly, taking it out of the box, tying the cover, checking, and packing.

Embodiment 2

[0364] Embodiment 2 formula: 1000 bottles of injection, 25g of total gambogic acid, 20g of L-arginine, 40g of mannitol, 2000ml of water for injection.

[0365] Take the prescribed amount of total gambogic acid, put it in a suitable container, add an appropriate amount of water for injection (80% of the total volume), stir well, add L-arginine to dissolve until clear, add mannitol, stir to dissolve, add 1% for injection Charcoal, stir for 30 minutes, decarbonize, add water for injection to a sufficient amount, after the determination of the intermediate content is qualified, under sterile conditions, filter with a 0.22 microporous membrane, and fill the filtrate into 10ml vials, 2ml per bottle.

Embodiment 3

[0367] Cut the garcinia resin into small particles, crush it into powder (about 10 mesh) with a pulverizer, put 600g of the garcinia powder in a 3000ml Erlenmeyer flask, add 1500ml of pyridine, shake it, let it stand for 30 minutes, then transfer it to a water bath at 85°C to heat Soak for 2 hours, shake constantly, filter while hot, wash the filter bottle with hot pyridine 3 times, 100ml each time, add 150ml of hot water at 60°C to the combined filtrate and washing solution, and place it in the refrigerator overnight. Take it out the next day, filter under reduced pressure, wash the filter cake twice with 70% pyridine, 80ml each time, and wash three times with distilled water, 60ml each time, after draining, dry under an infrared lamp to obtain 75g of dry product. Yield 12.5%.

[0368] Put the above dried product into a 1000ml round bottom flask, add 600ml of diethyl ether, reflux on a water bath to dissolve, let cool, filter out the insoluble matter, concentrate the filtrate...

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Abstract

The present invention provides a kind of new general gambogic acid preparation. The general gambogic acid preparation consists of general gambogic acid 12.5-37.5 wt%, L-arginine 10-30 wt% and mannitol 20-60 wt%. The present invention also includes the preparation process of the said preparation.

Description

Technical field: [0001] The invention relates to a traditional Chinese medicine preparation, in particular to total gambogic acid, a preparation containing it and a preparation method thereof. Background technique: [0002] Garcinia cambogia is a dry resin secreted by Garcinia cambogia, which was recorded in the United States Pharmacopoeia. Its active ingredients are mainly acidic effective parts such as gambogic acid, that is, total gambogic acid. In 1955, Amorosa obtained pure gambogic acid for the first time by making pyridinium salt crystallization. In 1965, the molecular structure was determined with the help of nuclear magnetic resonance, and the research work on gambogic acid continued to deepen. There are many literature reports on the preparation method of gambogic acid, among which there are mainly three. The first route is to soak the garcinia crumbs in acetone overnight, combine the acetone solution to obtain the acetone extract of garcinia resin, and after con...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/35A61P35/00
Inventor 陈庆才赵俊
Owner JIANGSU AOSAIKANG PHARMA CO LTD
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