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New use of recombinant hirudin

A recombinant hirudin and application technology, applied in the pharmaceutical field, can solve the problems of no pharmacological reports and clinical applications for the prevention and treatment of cataract diseases.

Inactive Publication Date: 2006-02-22
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But there is no pharmacological report and clinical application of prevention and treatment of cataract disease

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0037] Formula and preparation method of recombinant hirudin eye drops:

[0038] Recombinant Hirudin 0.25g

[0039] Boric acid 1.116g

[0040] Borax 0.191g

[0041] Sodium chloride 0.22g

[0042] EDTA0.5g

[0043] Chitosan 0.5g

[0044] Ethyl p-hydroxybenzoate 0.03g

[0045] Distilled water to 100ml

[0046] Boric acid, borax and water are added to prepare a buffer solution with a pH of 7.4, and the buffer solution is used to dissolve recombinant hirudin, EDTA, chitosan, sodium chloride, and hexyl p-hydroxybenzoate, mix well, filter, sterilize and subpackage to obtain The recombinant hirudin eye drops of the present invention.

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PUM

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Abstract

The present invention discloses a new application of recombinant hirudin for preparing medicine for preventing and curing catarct.

Description

technical field [0001] The present invention relates to the new application of recombinant hirudin, especially the application in the field of pharmacy. Background technique [0002] Hirudin is a protein containing 65-66 amino acids extracted from the salivary glands of medical leeches. It is a single-chain polypeptide with a molecular weight of 7000u. The secondary structure makes this domain stable, and the linear C-terminal sequence is used to bind thrombin. As a specific inhibitor of thrombin, it has strong anticoagulant activity, can effectively prevent and treat disseminated intravascular coagulation, and has a significant effect on diseases such as cardiovascular thrombosis and cerebral thrombosis. Due to the limited source of natural hirudin, bioengineering technology is widely used to prepare recombinant hirudin. The two most widely used cell expression systems are Escherichia coli (E.coli) and Saccharomyces cerevisiae (S.cerevisiae). The preparation method of rec...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/17A61P27/12
Inventor 吴梧桐谭树华崔莉李运曼
Owner CHINA PHARM UNIV
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