Vaginal gel tablets

A technology for gel sheet and vagina, which is applied in the field of gynecological vaginal gel sheet and can solve the problems of prolonging medication interval, mildewing of aqueous liquid preparations, and decreasing drug efficacy.

Inactive Publication Date: 2007-03-07
凌沛学
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Hydrophilic gel material is used as the matrix of vaginal gel. Because of its high viscosity and bioadhesion, the drug can be distributed in the mucosal space and folds to maintain long-term close contact with the mucosa; It is not easy to be excreted from the body, the drug has a long action time, high bioavailability of the drug and the advantages of prolonging the interval between medications; but because the gel has the advantages of large volume, production, carrying, transportation, storage, inconvenient use, high cost and water-based liquid preparations are easy to cause mildew Changes, easy to cause chemical degradation of drugs, lower drug efficacy or even failure, and poor stability, which limits its wide application
Vaginal effervescent tablets have the advantages of fast onset of action, easy mass production, convenient use, carrying, transportation, and storage, low cost, and good drug stability during storage; relatively short duration of action

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Shuangzotai Gel Tablets

[0017] Prescription (based on 1000 tablets)

[0018] Metronidazole 200g

[0019] Clotrimazole 160g

[0020] Chlorhexidine acetate 8g

[0021] Hydroxypropyl Methyl Cellulose 100g

[0022] Sodium bicarbonate 150g

[0023] Citric acid 100g

[0024] Starch 50g

[0025] 10% starch paste appropriate amount

[0026] Magnesium Stearate 3.5g

[0027] Preparation method: Metronidazole, clotrimazole, chlorhexidine acetate, hydroxypropyl methylcellulose, sodium bicarbonate, starch passed through 80 mesh sieve, mixed evenly, granulated with 10% starch paste; citric acid passed through 80 mesh Mesh sieve, granulate with 10% starch paste; the above two kinds of granules are dried at 60°C respectively, mixed evenly after granulation, added with magnesium stearate, mixed evenly, compressed into tablets, packed in double aluminum.

Embodiment 2

[0029] Nystatin Gel Tablets

[0030] Prescription (based on 1000 tablets)

[0031] Nystatin 50 million units

[0032] Carbomer 934 100g

[0033] Boric acid 120g

[0034] Sodium bicarbonate 100g

[0035] Microcrystalline Cellulose 130g

[0036] Pregelatinized starch 50g

[0037] Micronized silica gel 50g

[0038] Preparation method: take nystatin plus pregelatinized starch, grind it into fine powder, mix it with the remaining pregelatinized starch, and set aside; borax and sodium bicarbonate are passed through 80-mesh sieve respectively; microcrystalline cellulose and carbomer 934 are dried at 80°C and passed through 80 mesh sieve. Mix the above powder evenly, add micropowder silica gel, pass through a 40-mesh sieve, directly compress into tablets, and pack in double aluminum.

Embodiment 3

[0040] Nonoxynol Gel Tablets

[0041] Prescription (based on 1000 tablets)

[0042] Nonoxynol 75g

[0043] Xanthan gum 40g

[0044] Sodium bicarbonate 80g

[0045] Potassium Bitartrate 200g

[0046] Sodium Carboxymethyl Cellulose 100g

[0047] 10% starch paste appropriate amount

[0048] Magnesium Stearate 2.5g

[0049] Preparation method: pass nonoxynol ether, xanthan gum, and sodium carboxymethyl starch through a 80-mesh sieve, granulate with 10% starch paste, dry at 60°C and set aside; pass through a 80-mesh sieve for sodium bicarbonate and potassium hydrogen tartrate, respectively 10% starch paste was granulated, dried at 40°C and set aside. Mix the three kinds of granules, add magnesium stearate, mix evenly, press into tablets, and pack in double aluminum.

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PUM

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Abstract

A vaginal gel tablet for treating gynopathy contains hydrophilic gel material (1-40%) and effevescent disintegrant or superdisintegrant (20-50%). It advantages are quickly taking its effect and durable action.

Description

technical field [0001] The invention relates to a gynecological vaginal gel sheet, which belongs to the technical field of medicines. Background technique [0002] Vaginal mucosal administration has a history of nearly a hundred years. Compared with traditional oral administration, it has many advantages. It is a very effective drug sustained release system; it can be used not only locally, but also systemically. The drug is administered locally through the vaginal mucosa, which can increase the local drug concentration, give full play to the curative effect of the drug, and avoid systemic effects; the drug can exert a systemic effect through the absorption of the vaginal mucosa, which can avoid the hepatic first-pass effect of the drug, improve bioavailability, and reduce side effects , Also avoid the gastrointestinal reactions of some drugs. [0003] Common dosage forms for vaginal mucosal administration include suppositories, effervescent tablets and gels. Suppositories...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/00A61K9/20A61K9/46A61K47/38A61K47/04A61P15/02
Inventor 凌沛学张建强张玲
Owner 凌沛学
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