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Device and method for accelerating biological chip micro fluid reaction

A microfluidic reaction and biochip technology, applied in biochemical cleaning devices, biochemical equipment and methods, enzymology/microbiology devices, etc., can solve problems such as inability to stir

Active Publication Date: 2007-05-16
SHANGHAI BAIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when the amount of liquid is very small, stirring is often impossible due to lack of suitable utensils

Method used

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  • Device and method for accelerating biological chip micro fluid reaction
  • Device and method for accelerating biological chip micro fluid reaction
  • Device and method for accelerating biological chip micro fluid reaction

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0015] The technical solutions of the present invention will be further described below in conjunction with the accompanying drawings and embodiments.

[0016] Fig. 1 shows an exploded view of the main structure of a device 100 for quickening biochip microfluidic reactions, and Fig. 2 shows the overall structure of this kind of device 100, as shown in Fig. 1 and Fig. 2, this device 100 include:

[0017] A temperature control platform 102, the temperature control platform is inclined; in this embodiment, the angle of inclination is 5-60°. The temperature control platform must have a certain tilt angle, otherwise it will affect the progress of the reaction, which will be explained in detail later.

[0018] A biochip 104 is placed on the temperature control platform 102 .

[0019] A micro-reaction chamber 106 is pasted on the biochip 104, and two small holes 108 and 110 are opened on the top of the micro-reaction chamber 106. The reaction chamber is similar to a box without a ...

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Abstract

The device with fast biochip micro fluid reaction includes one slant temperature-controlling platform for biochip to be put on, micro reaction cabin with two holes on the top to be adhered to the biochip, plate covering the micro reaction cabin and fixed to the platform and with through holes corresponding to those in the cabin, two capillaries adhered to the holes in the plate and including one connected to a bi-directional peristaltic pump and the other connected to the reagent pipe, and two O-rings at the holes. The peristaltic pump is first rotated in forward direction to fulfill the micro reaction cabin with reagent from the reagent pipe and then rotated alternately in the forward direction and reverse direction. The present invention can increase the contact of the biological molecules in sample and reagent with the biochip to speed the reaction and raise biochip detected S / N ratio.

Description

technical field [0001] The invention relates to the field of biochips, and more specifically relates to a device and method for accelerating microfluidic reactions of biochips. Background technique [0002] Biochip is one of the major scientific and technological developments with the most epochal characteristics in the high-tech field in recent years. It is to orderly immobilize gene probes (oligonucleotide probes, cDNA clones, PCR products, etc.), antigen antibodies, etc., which can reflect a large amount of biological information in the sample, on solid supports (such as aldehyde groups, amino groups, sulfhydryl groups, etc.) , carboxyl and other active groups to form arrays on glass slides or silicon wafers, nylon membranes, nitrocellulose membranes), and through hybridization with actual samples (or amplified products), high-pass Quantitatively obtain information on all genes and proteins to be tested. The characteristics of parallel detection and high information thr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/68C12M1/00
Inventor 朱滨孙悦张宇邢军芬
Owner SHANGHAI BAIO TECH