Dimeric thrombopoietin peptide mimetics binding to MP1 receptor and having thrombopoietic activity

A technology of receptor binding and compounds, applied in the field of compounds, can solve problems such as lack of sequence homology
CN1325447AInactive Publication Date: 2001-12-05AMGEN INC
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
AMGEN INC
Publication Date
2001-12-05
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to the field of compounds, especially peptides or polypeptides, that have thrombopoietic activity. The peptides and polypeptides of the invention may be used to increase platelets of platelet precursors (e.g., megakaryocytes) in a mammal.
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Description

[0001] This application claims priority to US Provisional Application 06 / 105,348, filed October 23, 1998. field of invention

[0002] Basically, the present invention relates to the field of compounds, in particular peptides or polypeptides having thrombopoietic activity. The peptides or polypeptides of the present invention can be used in mammals to increase the production of platelets or platelet precursors such as megakaryocytes. Background of the invention

[0003] The present invention relates to the field of compounds, particularly peptides having the ability to stimulate the production of platelets and their precursors, such as megakaryocytes, in vitro and in vivo. Before discussing the properties of the compounds of the present invention, two proteins with thrombopoietic activity: thrombopoietin (TPO) and megakaryocyte growth and development factor (MGDF) are provided as background information below.

[0004] Cloning o...

Claims

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