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Nanoparticles with polymer shells

A technology of nanoparticles and polymers, applied in the field of nanoparticles, can solve problems that are poorly understood

Inactive Publication Date: 2001-12-26
内诺斯佩尔公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, little is known about such systems with nanometer dimensions (<100 nm)

Method used

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  • Nanoparticles with polymer shells

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0096] This example describes the preparation of novel metal-organic hybrid nanoparticles by, for example, figure 1 Ring-opening metathesis polymerization (ROMP), as described in , controls polymer growth on the surface of gold nanoparticle templates. In this method, organosoluble gold nanoparticles (GNPs) are modified with norbornene-terminated linear alkanethiols (2). Then, the ROMP catalyst (1) capable of enduring functional groups is used to directly initiate the polymerization reaction on the surface of the particles, and then the monomer raw material containing norbornene groups is injected into the solution of the initial nanoparticles.

[0097] Two tentative conceptual systems emerged. The first is GNPs with a polymer shell of ferrocene-3 functionalized with norbornene groups with redox activity. The second is GNPs functionalized with the initial unit of 3 and subsequently functionalized with another redox-active norbornenyl-containing monomer 4. The redox potential...

Embodiment 2

[0150] This example describes compound 5 (see Figure 4 )Synthesis. To a 100 mL Schlenk flask was added 2-norbornene-5-exo-ol (1.10 g, 10 mmol), 3-thiopheneacetic acid (1.42 g, 10 mmol) and p-toluenesulfonic acid monohydrate (80 mg, 0.42 mmol). The above three solids were dissolved in toluene (60 mL) and a Dean / Stark trap was fitted on top of the flask. A water condenser was placed on top of the Dean / Stark trap and the mixture was heated to reflux. Over 6 hours, the volume of the reaction mixture was reduced to 20 mL by occasionally collecting solvent from the bottom of the Dean / Stark trap. The mixture was cooled to room temperature, poured into water (50 mL), and extracted with ether (3 x 50 mL). The organic portions were combined, washed with brine (50 mL), dried over sodium sulfate, and filtered into a 500 mL round bottom flask. The solvent was removed under vacuum with a rotary evaporator. The resulting pale yellow oil was chromatographed on silica gel with 1:1 CH 2 ...

Embodiment 3

[0158] This example describes compound 6 (see Figure 4 )Synthesis. In an inert atmosphere glove box, exo-5-norbornen-2-ol (710 mg, 6.45 mmol) was weighed and placed in a 50 mL Schlenk flask. THF (15 mL) was added, and while the solution was vigorously stirred, sodium metal (160 mg, 6.96 mmol) was added free of oil. The mixture was then removed from the glove box, refluxed under nitrogen sparging for 12 hours, and allowed to cool to room temperature. In a separate 100 mL Schlenk flask, 2,5-dibromo-3-bromomethylthiophene (2.01 g, 6.00 mmol) was dissolved in THF (15 mL), and the flask was fitted with an isobaric dropping funnel. The cooled deprotonated exo-5-norbornen-2-ol solution was then transferred via cannula to an isobaric dropping funnel (excess Na was quenched with isopropanol) and, under vigorous stirring, Add slowly to the thiophene solution over 10 minutes. Afterwards, the dropping funnel was replaced with a condenser, and the mixture was refluxed for another 12 h...

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Abstract

A propagation monomer having the formula P-L-N, wherein: P is a moiety which has redox activity, optical activity, electronic activity, or magnetic activity; N is a cyclic olefin-containing group; L is a bond or linker whereby N is attached to P. The monomers are useful in a method of detecting or quantitating an analyte comprising contacting the analyte with a type of binding monomers having the formula N-L-B wherein: N is a cyclic olefin-containing group; B is a binding moiety that binds specifically to the analyte; and L is a bond or a linker whereby N is attached to B; so that the binding monomers bind to the analyte, and then adding the propagation monomers so that the propagation monomers polymerize to form a polymer attached to the analyte. The properties of the polymer attached to the analyte can be detected or measured in order to detect or quantitate the analyte.

Description

[0001] This application claims the benefit of divisional application 60 / 110327, filed November 30,1998. [0002] This invention was made with support from ARO to MURI under Grant No. DAAG55-97-1-0133. The United States Government may have various rights in this invention. field of invention [0003] The present invention relates to nanoparticles having thereon a polymer shell which imparts one or more selected properties to the nanoparticles. The present invention also relates to a process for the preparation of such nanoparticles by ring-opening metathesis polymerization of transition metals and derivatives of cyclic alkenes, preferably norbornene, with selected properties. This method allows the polymer to grow off the surface of the nanoparticles. The invention also relates to certain novel monomers and polymers and methods for their preparation, and to kits for detecting or quantifying analytes. Background of the invention [0004] In recent years, there has been trem...

Claims

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Application Information

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IPC IPC(8): G01N33/553A61K47/48B01J19/00C08G61/06G01N33/533G01N33/543G01N33/545G01N33/58
CPCB82Y5/00B82Y30/00G01N33/533G01N33/54346G01N33/582G01N33/583G01N33/587
Inventor 查德·A·米尔金桑宾·T·努延
Owner 内诺斯佩尔公司
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