Synthesis of fused liquid crystal of chitosan grafted polylactic acid

A synthesis method, chitosan technology, applied in the field of synthesis of chitosan-grafted polylactic acid melt-induced liquid crystals, can solve the problems of application limitations, unclear physiological effects of polyvinyl alcohol, poor hydrophilicity, etc., and achieve excellent biophase Capacitance, excellent biodegradability, effect of improving solubility

Inactive Publication Date: 2003-01-01
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the poor hydrophilicity of its surface, the degradation time in the human body is long, so that it causes adverse reactions in the body
For a long time, people have used other hydrophilic and water-soluble materials to improve the surface hydrophilic properties of polylactic acid, such as

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Implementation of chitosan with 50% deacetylation degree and lactide molar ratio of 1:1.

[0013] The chitosan with a deacetylation degree of 50% was dried in a vacuum oven for 48 hours to remove the adsorbed water on its surface. Weigh 0.05 mol of chitosan and add it to the reactor, pour nitrogen into it repeatedly three times, then degas under vacuum for 1 hour, add 40 ml of dried toluene as a dispersant, and prepare it into a 1.25 mol toluene dispersion . Weigh 0.05 mol of triethylaluminum to prepare a 15% toluene solution. Add the triethylaluminum solution dropwise to the chitosan toluene dispersion at room temperature, and react for another 1 hour when no gas is generated. Add 0.05 mol of lactide degassed by vacuum for 1 hour, then place the reactor in an oil bath pre-heated to 70°C, react for more than 20 hours, pour the reaction solution into ethanol to allow it to fully precipitate, and filter and dry After obtaining the product. Because the deacetylation de...

Embodiment 2

[0015] The implementation of chitosan and lactide with a degree of deacetylation of 94% at a ratio of 1:1.

[0016] The chitosan with a deacetylation degree of 94% was dried in a vacuum oven for 48 hours to remove the adsorbed water on its surface. Weigh 0.05mol chitosan and add it into the reactor, flush with nitrogen three times, and then degas under vacuum for 1 hour. Add 60 ml of dried toluene as a dispersant to prepare a 0.83 mole toluene dispersion. Weigh 0.05 mol of triethylaluminum to prepare a 15% toluene solution. Add the triethylaluminum solution dropwise to the chitosan toluene dispersion at room temperature, and react for another 1 hour when no gas is produced. Add 0.05 mol of lactide that has been vacuum degassed for 1 hour, then place the reactor in an oil bath pre-heated to 70°C, and after 20 hours of reaction, pour the reaction solution into ethanol to make it fully precipitate, filter and dry After obtaining the product. In this embodiment, chitosan with ...

Embodiment 3

[0018] Acetyl degree 94% chitosan and lactide 1:60 implementation.

[0019] The chitosan with a deacetylation degree of 94% was dried in a vacuum oven for 48 hours to remove the adsorbed water on its surface. Weigh 0.005 mol of chitosan and add it into the reactor, flush with nitrogen for three times, and then degas under vacuum for 1 hour. Add 100 ml of dried toluene as a dispersant to prepare a 0.05 mol toluene dispersion. Weigh 0.005 mol of triethylaluminum to prepare a 15% toluene solution. Add the triethylaluminum solution dropwise to the chitosan toluene dispersion at room temperature, and react for another 1 hour when no gas is produced. Add 0.3 mol of lactide that has been vacuum degassed for 1 hour, then place the reactor in an oil bath preheated to 70°C, and after 20 hours of reaction, pour the reaction solution into ethanol to make it fully precipitate, filter and dry After obtaining the product. Due to the use of chitosan with a high degree of deacetylation and...

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PUM

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Abstract

The synthesis of fused liquid crystal of chitosan grafted polylactic acid includes vacuum deairing of chitosan for 1 hr, charging nitrogen, adding toluene as dispersant, dripping toluene solution of aluminium ethide as catalyst in 1-3 molar times of chitosan, ring opening polymerization of lactide inside solution to produce grafted copolymer of chitosan and polylactic acid. The grafted copolymer of the present invention has special performance, and may be used as interface coupling agent for polymer blend of chitin, chitosan and polylactic acid as well as medicine delayed releasing material and other human body implanting biological material. In addition, it has the performance of fused liquid crystal and thus may be produced into various biological material.

Description

Technical field: [0001] The invention relates to a method for synthesizing chitosan-grafted polylactic acid melt-tropic liquid crystals. During the heating process, the synthesized material can appear in the melting state of chitosan, which does not exist in the heating process, so the chitosan can be enlarged. Processing range, such as high-strength fibers obtained by melt spinning in a liquid crystal state, may be used as sutures for surgical operations and reinforcing fibers for other biocomposites; and directly processed into other biomaterial-related products in a molten state. Background technique: [0002] Chitin is the second largest naturally synthesized polymer material next to cellulose, and the annual output of this material by biosynthesis is as high as nearly one billion tons. However, due to the three-dimensional hydrogen bond structure in the chitin molecule, it has neither a specific melting point nor is it soluble in common solvents, which greatly limits it...

Claims

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Application Information

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IPC IPC(8): C08B37/08C08G81/00
Inventor 刘预田丰陈刚胡克鳌
Owner SHANGHAI JIAO TONG UNIV
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