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Compositions comprising edible oils or fats and phytosterols and/or phytostanols substantially dissolved therein

A technology for plant stanols and plant sterols, which can be applied in the directions of edible oil/fat, preservation of fatty substances by additives, drug combination, etc., and can solve the problems of unsatisfactory realization and the like

Inactive Publication Date: 2003-04-30
FORBES MEDI TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] Therefore, it would be highly desirable to provide a method for dissolving phytosterols / phytostanols in oils and fats to obtain products usable per se, or for incorporation into transport vehicles without further modification, which has not hitherto been satisfactorily achieved.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example

[0043] The oil and fat composition containing substantially completely dissolved phytosterols of the present invention can be used directly as an agent for lowering serum cholesterol in animals, especially humans, for cooking, baking, etc. without further modification. Alternatively, the composition can be manipulated to enhance transport into various other media. For example, the formation of oleaginous food products incorporating such compositions, such as peanut butter, mayonnaise, ice cream, and margarine spreads, is fully encompassed by the invention. There are a variety of modes or "vehicles" for the delivery of such compositions, and thus the invention is not intended to be limited to the following examples of delivery. 1) pharmaceutical form :

[0044] It is within the scope of the present invention that the composition of the present invention may be incorporated into various conventional pharmaceutical preparations and dosage forms, such as tablets (plain and coa...

Embodiment

[0057] The invention is described by the following non-limiting examples: Example 1: Solubilization of oil-phytosterols in soybean oil

[0058] A number of compositions containing phytosterols dissolved in oil have been prepared without the use of emulsifiers.

[0059]A) A phytosterol mixture (hereinafter referred to as "3P6") comprising β-sitosterol, campesterol, campestanol, sitostanol (the latter approximately 33-40% by weight) is selected for dissolution in in soybean oil. 0.5 g of 3P6 (5% by weight) was heated to a molten state in an oil bath at about 140°C. The molten phytosterol mixture was added to 9.5 grams of soybean oil (95% by weight) at about 140°C. When the temperature dropped to 100-110°C, the final composition was mixed for about 2 minutes.

[0060] B) 0.6 g of 3P6 (6% by weight) was heated to a molten state in an oil bath at about 140°C. The molten phytosterol mixture was added to 9.4 grams of soybean oil (94% by weight) at about 140°C. When the temperatu...

Embodiment 2

[0065] The 5% by weight phytosterol composition thus formed produced a clear solution with no discernible precipitates or crystals and was the most preferred composition without emulsifiers. A control sample composition with similar component percentages was prepared simply by adding the oil and phytosterol together and heating for about 3 minutes. Each of the compositions prepared by the method of the invention was clearer than the control sample, indicating greater dissolution of the phytosterols. Example 2: Dissolution of Oil-Phytosterols and Emulsifiers in Soybean Oil

[0066] Three types of emulsifiers were tested: EMULTOP TM (lecithin enriched with lyso-PC); EPIKURON 200 TM (contains greater than 98% phospholipids) and Phosphoderm TM (about 80% phospholipids in ethanol). Each of these three was tested in an amount ranging from 0.01% by weight to 1% by weight. The amount of phytosterols ranges from 5-10% by weight. The protocol described below for each set amount of...

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PUM

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Abstract

The invention relates to a composition comprises an edible oil or fat and one or more phytosterols and / or phytostanols, wherein the phytosterols and / or phytostanols are substantially completely dissolved therein by a method in which the phytosterols and / or phytostanols are heated to form a molten material which is then added to a heated oil or fat and the composition so formed is cooled to room temperature.

Description

technical field [0001] The present invention relates to phytosterols and phytostanols and their incorporation into oils and fats. Background technique [0002] Prevention of atherosclerosis, an underlying cause of cardiovascular disease ("CVD"), has not been adequately studied despite recent scientific and technological advances that have helped improve the quality of human life and extend human lifespan. Atherosclerosis is a degenerative process caused by the interaction of genetic factors and environmental factors such as diet and lifestyle. Research to date suggests that cholesterol may play a role in atherosclerosis by forming atherosclerotic plaques in blood vessels that eventually cut off blood supply to the heart muscle or the brain or extremities, depending on where the plaque is located in the arterial tree (1, 2). A review has indicated that a 1% reduction in a person's total serum cholesterol reduces the risk of coronary events by 2% (3). Statistically, a 10% r...

Claims

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Application Information

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IPC IPC(8): A23G1/30A21D2/16A21D2/36A21D13/00A23C9/13A23C9/152A23D9/007A23D9/02A23G1/00A23L1/30A61K9/107A61K9/48A61K31/575A61K38/00A61K45/06A61P3/06A61P9/00C11B5/00
CPCA23V2002/00A61K9/4858A61K31/575A23L1/3004A21D2/165A23D9/02A23C9/13A23D9/007A21D2/36A61K9/1075A23C9/152A61K45/06A23L33/11A61P3/06A61P9/00A61K2300/00A23V2250/18A23V2250/2136
Inventor 耶日·扎维斯托夫斯基
Owner FORBES MEDI TECH
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