Preparation method of phytostanol ester by taking ionic liquid as catalyst

A technology of phytostanol esters and phytostanols, which is applied in the field of preparing fatty acid or hydroxy acid phytostanol esters, can solve the problems of limited application range, poor fat solubility and water solubility of phytostanols, and achieve The effect of convenient preparation, green synthesis route, and expanded application range

Inactive Publication Date: 2012-08-01
JIANGNAN UNIV
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0003] However, the fat-solubility and water-solubility of phytostanols are poor, which limits its practical application range.

Method used

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  • Preparation method of phytostanol ester by taking ionic liquid as catalyst

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Comparison scheme
Effect test

Embodiment 1

[0020] Add 2.08g of phytostanol and 6.00g of lauric acid into a reaction test tube with a branch, blow nitrogen, dissolve completely at 130°C under magnetic stirring conditions, add 0.13g of [bmim]Cl-ZnCl 2 , and controlled the temperature of 130 ° C under the condition of esterification for 6 hours, separated and purified to obtain lauric acid phytostanol ester.

Embodiment 2

[0022] Add 2.08g of phytostanol and 4.05g of myristic acid into a reaction test tube with a branch, blow nitrogen, dissolve completely at 135°C under magnetic stirring conditions, add 0.08g of [bmim][HSO 4 ], esterification reaction at a controlled temperature of 135 ° C for 5 h, separation and purification of phytostanol myristate.

Embodiment 3

[0024] Add 1.04g phytostanol and 3.50g linoleic acid into a reaction test tube with a branch, blow nitrogen, dissolve completely at 160°C under magnetic stirring, add 0.05g [bmim]Cl, control the temperature at 160°C The reaction was carried out for 4 hours, and the linoleic acid phytostanol ester was obtained by separation and purification.

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Abstract

The invention relates to a novel preparation method of a phytostanol ester by taking an ionic liquid as a catalyst. The technical scheme adopted by the invention is as follows: in the absence of solvents and in the presence of nitrogen, a fatty acid (saturated or unsaturated acid) and phytostanol are heated to 90 to 180 DEG C to be melted completely, and are added with a catalyst to be subjected to an esterification reaction for 1 to 15 hours by controlling the temperature between 90 DEG C and 180 DEG C; a hydroxy acid, the phytostanol and the catalyst are added to a benzene, toluene or xylene solvent, and are heated to 80 to 115 DEG C to be subjected to the esterification reaction for 5 to 20 hours at this temperature; and after the end of the reaction, the phytostanol ester is obtained by separation and purification. The ionic liquid used in the method does not pollute the environment, has no obvious corrodibility, and is easy to recycle and reuse; the conversion rate of the phytostanol is high; and the product is convenient to recover, and the operation is simple.

Description

technical field [0001] The invention relates to a method for preparing phytostanol esters, in particular to a method for preparing fatty acid (saturated or unsaturated acid) or hydroxy acid phytostanol esters by using ionic liquid as a catalyst. Background technique [0002] Phytosterols and phytostanols are the plant equivalents of animal cholesterol. They can form a competitive absorption relationship with cholesterol in the small intestine, replace part of the cholesterol to be absorbed, and cannot be used by themselves, so as to reduce the low-density lipoprotein cholesterol in the blood. level of efficacy. Research results in recent decades have shown that phytosterols are a class of natural substances with no toxic side effects on the human body and high physiological activity. The Food and Drug Administration (FDA) has approved phytosterols and phytostanols as a food Additives used. [0003] However, the fat solubility and water solubility of phytostanols are poor, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07J75/00C07J9/00
Inventor 冯骉李静静何文森贾承胜张晓鸣杨叶波潘晓霞
Owner JIANGNAN UNIV
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