High water-soluble povidone-iodine cream

Abstract

The invention is a kind of high water-solubility povidone iodine film agent, it is made from povidone iodine and high water-solubility filming material polyethylene alcohol, the weight ratio is 1:1-1:100, the polyethylene alcohol is selected from the first class polyethylene alcohol by which the film agent is made up, the film agent can be dissolved in half an hour at 37 deg.C, such as polyethylene alcohol 05-88, 04-88, and the compound of them at any rate. The manufacturing method is: the povidone iodine is added to the water and heated to 40-100 deg.C, after it is dissolved, the polyethylene alcohol and plasticizer are added and heated under 80-100 deg.C for an hour, they are dissolved evenly; they are cooled to 40-70% and are mixed to remove bubbles, then they are placed on the board, they are dried under 60-100 deg.C for 30-60 minutes, removes the film and slices them into pieces.

Description

technical field [0001] The invention belongs to the technical field of iodine-containing disinfectant and bactericide, and specifically relates to a povidone-iodine film agent for treating burns, skin ulcers and gynecological diseases, especially for preventing sexually transmitted diseases and contraception during sexual intercourse. technical background [0002] Povidone-iodine is a broad-spectrum, high-efficiency, low-toxicity, and safe disinfectant. It has a good killing effect on bacteria, fungi, viruses, protozoa, etc., and can be used to treat burns, skin ulcers, gynecological diseases, prevention and auxiliary treatment of sexually transmitted diseases. At present, the dosage forms of povidone-iodine include solution, suppository, ointment, and gel. However, the solution has poor stability, is easy to lose, and cannot maintain effective drug concentration for a long time; the two types of dosage forms of ointment and gel have small drug loading and are inconvenient ...

AI Technical Summary

Problems solved by technology

Since the film-forming material polyvinyl alcohol 17-88 used has poor water solubility, it needs to be dissolved in water at a higher temperature, such as 80°C-90°C water bath, so the prepared film has poor water solubility, and the water solubility requirements The high application environment cannot be applied, and the application range is limited

Therefore, although povidone-iodine has the characteristics of broad spectrum, low toxicity, high efficiency and safety, its application is limited due to the shortcomings of current products such as inconvenient use, poor stability or poor water solubility.