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Clamycin medicinal preparation

A technology for clarithromycin and preparations, which is applied to the field of ophthalmic preparations containing clarithromycin, and achieves the effects of good stability, few adverse reactions and convenient use.

Inactive Publication Date: 2004-02-18
GUANGZHOU PUIS PHARMA FACTORY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

And there is no report that roxithromycin is made into eye drops

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Take 5g of clarithromycin, grind it finely in a sterilized mortar, add 10ml of sterilized water for injection, grind it into a fine paste, then add yellow petrolatum in equal amounts step by step to 1000g, grind it evenly, and pack it into 1000 sachets.

Embodiment 2

[0017] Take 10g of clarithromycin, grind it into a sterilized mortar, add 10ml of sterilized water for injection, grind it into a fine paste, then add yellow petroleum jelly in equal amounts step by step to 1000g, grind it evenly, and pack it into 1000 sachets.

Embodiment 3

[0019] Take 10g of clarithromycin lactobionate, put it into a sterilized mortar and grind it finely, add 10ml of sterile water for injection and grind it into a fine paste, then add yellow petrolatum in equal amounts to 1000g, grind it evenly, and pack it into 1000 small bags, that is, have to.

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PUM

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Abstract

A clamycine preparation is prepared from clamycine, pharmacologically receptable salt 0.1%-3.0%, cream matrix and / or other carrier.

Description

Technical field: [0001] The invention relates to a pharmaceutical preparation of macrolide antibiotics, in particular to an ophthalmic preparation containing clarithromycin. Background technique: [0002] Macrolides are weakly basic antibiotics produced by streptomycin. They are named for their molecules containing 14 or 16-membered rings. Erythromycin is the most typical representative of this class of drugs. Macrolide antibiotics produce antibacterial effects by binding to the 50S subunit on the 70S nucleoprotein of bacteria to inhibit protein synthesis. Erythromycin has been used clinically for many years and is a relatively mature product on the market. Erythromycin has strong antibacterial activity against Staphylococcus (including enzyme-producing strains), various groups of Streptococcus and Gram-positive bacteria. It also has inhibitory effects on Legionella, Campylobacter fetalis, certain spirochetes, Mycoplasma pneumoniae, Rickettsia and Chlamydia. At present, e...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P27/02
Inventor 贝庆生
Owner GUANGZHOU PUIS PHARMA FACTORY
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