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Vegetable oil fatty milk oral or injection preparation

A technology of injection preparations and vegetable oils, applied in the field of medicine, can solve problems such as damaged DNA replication templates, increased frequency of sister chromatid exchange in human lymphocytes, and mutagenicity

Inactive Publication Date: 2004-03-24
XIAN LIBANG PHARMA TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although Tween 80 has a good solubilizing effect, it also has certain pharmacological effects and toxicity, such as an inhibitory effect on the heart; it can cause a slight drop in blood pressure; it still has an effect on the stability of red blood cells; it can induce sister staining of human lymphocytes The frequency of monomer exchange is increased, and the template of DNA replication is damaged, which has the possibility of mutagenicity

Method used

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  • Vegetable oil fatty milk oral or injection preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Embodiment 1: turmeric oil fat emulsion oral or injection preparation (0.1%, weight content)

[0031] prescription:

[0032] Curcuma Oil 1.0g

[0033] Soybean oil (for injection) 99.0g

[0034] Lecithin (for injection) 12g

[0035] Glycerin 22g

[0036] Add water for injection to 1000ml

[0037] Take 1.0g of refined curcuma oil, 99g of soybean oil, add 12g of lecithin, stir for about 10 minutes to mix, and take 800ml of water for injection, add 22g of glycerin. Under the condition of nitrogen protection, the phospholipid oil solution was added into the aqueous glycerin solution, and the total amount was adjusted to 1000 ml. Homogenize 7-8 times with a high-pressure homogenizer, the homogenization pressure is 100MPa, until the particle size ranges from 180nm to 300nm, adjust the pH to 7.0-8.0, filter, subpackage, inject nitrogen, and seal. Sterilize at 115°C for 30 minutes, and pack after passing the light inspection. Store ...

Embodiment 2

[0038] Embodiment 2: turmeric oil fat emulsion oral or injection preparation (1%, weight content)

[0039] prescription:

[0040] Curcuma Oil 10g

[0041] Soybean oil (for injection) 90g

[0042] Lecithin (for injection) 12g

[0043] Glycerin 22g

[0044] Add water for injection to 1000ml

[0045] Take 10g of refined curcuma oil, 90g of soybean oil, add 12g of lecithin, stir for about 10min to mix, and take 800ml of water for injection, add 22g of glycerin. Under the condition of nitrogen protection, the phospholipid oil solution was added into the aqueous glycerin solution, and the total amount was adjusted to 1000 ml. Homogenize 7-8 times with a high-pressure homogenizer, the homogenization pressure is 100MPa, until the particle size ranges from 180nm to 300nm, adjust the pH to 7.0-8.0, filter, subpackage, inject nitrogen, and seal. Sterilize at 115°C for 30 minutes, and pack after passing the light inspection. Store below 25°C. ...

Embodiment 3

[0046] Embodiment 3: turmeric oil fat emulsion oral or injection preparation (5%, weight content)

[0047] prescription:

[0048] Curcuma Oil 50g

[0049] Soybean oil (for injection) 50g

[0050] Lecithin (for injection) 12g

[0051] Glycerin 22g

[0052] Add water for injection to 1000ml

[0053] Take 50g of refined curcuma oil, 50g of soybean oil, add 12g of lecithin, stir for about 10min to mix, and take 800ml of water for injection, add 22g of glycerin. Under the condition of nitrogen protection, the phospholipid oil solution was added into the aqueous glycerin solution, and the total amount was adjusted to 1000 ml. Homogenize 7-8 times with a high-pressure homogenizer, the homogenization pressure is 100MPa, until the particle size ranges from 180nm to 300nm, adjust the pH to 7.0-8.0, filter, subpackage, inject nitrogen, and seal. Sterilize at 115°C for 30 minutes, and pack after passing the light inspection. Store below 25°C....

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Abstract

The present invention discloses a vegetable oil fat emulsion oral or injection preparation. Its main composition includes medicinal vegetable oil, lecithin as emulsifier, refined soybean oil or other refined oil as oil-soluble diluting agent and glycerine as isoosmotic regulating agent. It can reduce irritation of medicine and cosolvent to blood vessel, and can raise medicine effect.

Description

1. Technical field [0001] The invention belongs to the field of medicine and relates to fat emulsion preparations, in particular to vegetable oil fat emulsion oral or injection preparations. 2. Background technology [0002] Aromatic plants and essential oils have long been used extensively in traditional medicine such as Hepcratic medicine and Ayur Beda. The legendary spice "Maihelianxiang" in the Greek era is said to be able to cure "any inflammation". Ancient Greek physicians used various aromatic substances as medicine, and relying on aromatic substances to fumigate is one of their means of treating diseases. In the 17th and 18th centuries, the distillation technology of essential oils was greatly improved, and it was the era when essential oils were widely used in medicine and cosmetics. Since the middle of the 19th century, essential oils, like medicinal plants, were not regarded as therapeutic drugs by people, but scientific progress has in turn proved the medical ef...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61P31/00
Inventor 陈涛惠民权杨治旻王九成韩欢牛
Owner XIAN LIBANG PHARMA TECH
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