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Chinese medicine compound preparation for treating depression

A technology for depression and preparations, applied in the field of traditional Chinese medicine, can solve the problems of patients' toxic and side effects, expensive costs, etc.

Inactive Publication Date: 2004-04-28
TSINGHUA UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Depression is a chronic disease, and most western medicines have side effects or addiction. Long-term use of the above antidepressants not only requires high costs, but also brings great toxic and side effects to patients
[0004] At present, there is no special antidepressant traditional Chinese medicine, but the clinical accumulation of Chinese medicine for thousands of years has many effective prescriptions and medicines for depression. It is inevitable to research and develop them

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Prescription composition:

[0037] Anemarrhena 1400g

[0038] Epimedium 500g

[0039] Ginseng 100g

[0040] Preparation Process:

[0041] Add 6 times the amount of 95% ethanol to the raw materials in the above prescription, heat and reflux to extract 3 times, each time for 1.5 hours. The three extracts were combined, the ethanol was recovered under reduced pressure and concentrated to a concentration of 0.5 g crude drug / mL. After suction filtration, the relative density of the filtrate was about 1.10 (20°C). Above-mentioned filtrate is 10L macroporous adsorption resin column by volume, first elution with deionized water or distilled water of 6 times of resin column volume, then elution with 95% ethanol of 3 times of resin column volume, collect ethanol eluent, remove Solvent, obtain raw material drug. Pack into capsules to get the capsules of the present invention. Each capsule contains 0.2g.

[0042] In raw materials, containing total flavonoids and icariin (C ...

Embodiment 2

[0044] Prescription composition:

[0045] Anemarrhena 2400g

[0046] Epimedium 1200g

[0047] Ginseng 500g

[0048] Preparation Process:

[0049] Add 10 times the amount of water to the raw materials in the above prescription, heat and reflux to extract 6 times, each time for 2.5 hours. The 6 extracts were combined, the ethanol was recovered under reduced pressure and concentrated to a concentration of 0.5 g crude drug / mL. After suction filtration, the relative density of the filtrate was about 1.10 (20°C). The above-mentioned filtrate is eluted with 10 times of deionized water or distilled water of the volume of the resin column through a macroporous adsorption resin column with a volume of 10 L, and then eluted with 95% ethanol of 5 times of the volume of the resin column, and the ethanol eluate is collected and removed. Solvent, obtain raw material drug. Pack into capsules to get the capsules of the present invention. Each capsule contains 0.2g.

[0050] In raw mater...

Embodiment 3

[0052] Prescription composition:

[0053] Anemarrhena 1800g

[0054] Epimedium 900g

[0055] Ginseng 300g

[0056] Preparation Process

[0057] Add 8 times the amount of 70% ethanol to the raw materials in the above prescription, heat and reflux to extract 5 times, each time for 2 hours. The five extracts were combined, the ethanol was recovered under reduced pressure and concentrated to a concentration of 0.5 g crude drug / mL. After suction filtration, the relative density of the filtrate was about 1.10 (20°C). Above-mentioned filtrate is 10L macroporous adsorption resin column by volume, first with the deionized water or distilled water elution of 8 times of resin column volume, then with the 95% ethanol elution of 4 times of resin column volume, collect ethanol eluate, remove Solvent, obtain raw material drug. Pack into capsules to get the capsules of the present invention. Each capsule contains 0.2g.

[0058] In raw materials, containing total flavonoids and icariin ...

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Abstract

The present invention provides a kind of Chinese medicine preparation for treating depression. The medicine preparation is prepared with epimedium and anemarrhena rhizome as chief medicine material and ginseng as adjuvant, which are extracted with water or ethanol to obtain the effective components. The medicine is prepared into capsule, tablet, granule and other preparation forms. The cooperation of the three medicine materials can invigorate vital energy and Yin, nourish the heart and invigorate spleen vital energy to cure depression. Experiment shows that the medicine has specific inhibiting effect on several kinds of depression model, can raise the 5-hydroxy tryptamine and dopa level in the brain of animal with depression, and can resist exhaust of monoamine transmitter caused by reserpine.

Description

technical field [0001] The invention relates to a compound traditional Chinese medicine preparation for treating depression and a preparation process thereof, in particular to a Chinese patent medicine prepared according to a specific process using Anemarrhena, Epimedium and Ginseng as raw materials, and belongs to the field of traditional Chinese medicines. Background technique [0002] Depression is a neurosis characterized by persistent low mood, anxiety, physical discomfort, and sleep disturbance. With the aging of society and increasing social pressure, the incidence of depression increases year by year. An epidemiological study in the United States shows that 15% of people in the community have depressive symptoms (Blazer, D., Burcherr, B ., Service, C., George, L.K. The association of age and depression aming the elderly: an epidemiologic exploration. J. Gerontol, 1991, 46, 210-215). A European study came to the same conclusion (Dufouil, C., Dartigues, J.F., Fuhrer, ...

Claims

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Application Information

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IPC IPC(8): A61P25/24
Inventor 杜力军邢东明丁怡王锦刚刘祥成
Owner TSINGHUA UNIV