Compositions comprising extract of ganoderma lucidum, oleamide and its structural analogue as an effective component for preventing or treating dementia

A technology of Ganoderma lucidum extract and octadecenoyl, applied in the field of compositions with Ganoderma lucidum extract, octadecenamide and its derivatives as active ingredients for the prevention and/or treatment of dementia, to achieve inhibition of acetylcholine Esterase activity, effect of prevention and/or treatment of vascular dementia
CN1523994AInactive Publication Date: 2004-08-25钱吉子 +2
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
钱吉子
Publication Date
2004-08-25
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention is related to a composition for preventing and treating dementia containing the extracts of ganoderma lucidum, oleamide and its structural analogues as effective components. Since the composition according to the present invention prevents reduction of the amount of acetylcholine in the brain and shows the protective effect for cerebral tissues damaged by cerebral ischemia as it inhibits the activity of acetylcholinesterase (AChE) of animal cerebral tissues, it may be used for a prevention and treatment agent not only for the Alzheimer's disease but also vascular dementia.
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Description

technical field

[0001] The present invention relates to a pharmaceutical composition for preventing and / or treating dementia, which contains Ganoderma lucidum extract, octadecenamide and derivatives thereof as active ingredients. Background technique

[0002] Dementia is a pathological phenomenon different from normal aging. According to its etiology, it is divided into Alzheimer type dementia, vascular dementia, and dementia caused by sequelae of alcoholism, trauma, and Parkinson's disease.

[0003] Although the pathogenesis of Alzheimer's dementia is still unclear, it is known that most patients are accompanied by a decrease in acetylcholine in the central nervous system. Therefore, the method of increasing the concentration of acetylcholine in the brain with acetylcholine precursors or drugs that hinder the decomposition of acetylcholine has been used to treat Alzheimer's dementia. Drugs that inhibit acetylcholinesterase or in combination with known cholinesterase inhib...

Claims

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