Synthetic method of 2-(2-nitroethylenyl)-furan and its purpose as anti-coccidium agent

A technology of nitroethylene and furan, applied in the fields of animals and humans, can solve the problems such as not being described in the aspect of synthesis

Inactive Publication Date: 2005-01-26
CENT DE BIOACTIVOS QUIMICOS CBQ
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] Also, in some patents, 2-(2-nitrovinyl)-furan is used as part of a synergistic mixture for the production of industrial antimicrobial agents, but these patents do not describe aspects related to their synthesis

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] 2-(2-Nitrovinyl)-furan was synthesized by the method of the present invention, but several parameters were changed within the reported range. Table 1 shows the purity of 2-(2-nitrovinyl)-furan synthesized in a 6-liter reactor under different test conditions.

[0024] Synthesis number

[0025] (*) The purity percentage is determined by HPLC method.

Embodiment 2

[0027] In order to test the activity of the synthesized product, first dissolve 2-(2-nitrovinyl)-furan in 3% ethanol, and then dissolve it in water. As shown in Table 2, the alcohol-water solution adopts different concentrations ( 2, 4, 8ug / ml).

[0028] Use male F1 fatten chicks that are only 1 day old without coccidia. The birds are stored under suitable conditions to keep them free of coccidia until they are two weeks old. For feeding, use the same food as fatten chicks, except that the food does not contain anticoccidial agents.

[0029] Divide poultry of the same weight into 5 groups, each with 12 birds, use a kind of esophageal intubation to receive 1×10 orally 5 Eimeria tenella eggs are inoculated. Treatment starts when the chicks grow to 15 days, 24 hours before receiving the vaccination, and the treatment time is 9 days. In order to evaluate the effectiveness of the product, the increase in body weight (% compared to the initial body weight) and the approximate number of ...

Embodiment 3

[0033] The 2-(2-nitrovinyl)-furan formulation similar to the formulation described in Example 2 was put into drinking water twice a day (8 am and 12 pm) for 5 days, giving 2000 Only 56-84-day-old Leghorn chickens, which are naturally infected with Eimeria, are laying eggs. In the two houses highly infected with caecal coccidia, the 2000 birds in each house died an average of 119 in 5 days. Collect the data of these two houses. Investigating and researching when bloody diarrhea occurs in poultry, typical cecal damage can be observed and a large number of parasite eggs can be found in the cecal content. Infected poultry in one house served as an untreated control group, while uninfected poultry in another house served as a non-infected or treated control group of the same age.

[0034] In order to evaluate the effectiveness of the product, the table design of Example 2 is appropriately used, except that the weight control is not included. In addition to the weight control group, 10 ...

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PUM

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Abstract

The invention relates to a method of obtaining and purifying 2-(2-nitrovinyl)furane consisting in reacting furfural and nitromethane, using isobutylamine as a catalyst and activated carbon as an adsorbent, in order to obtain a product of pharmaceutical quality. Said technique considerably reduces the environmental impact by eliminating the gaseous waste from the system by means of absorption in water. The inventive pharmaceutical composition contains 2-(2-nitrovinyl)furan and has powerful action against low concentrations of coccidia.

Description

Technical field [0001] The present invention relates to animals and humans, and more specifically, to a product with strong anticoccidial activity. It has shown satisfactory results in experiments and industrial development of animals as a source of food. Background technique [0002] According to reports, in scientific papers and patent information, furan products, especially nitrofuran compounds, have an anti-coccidial effect. Although these compounds are still available on the market, their consumption is declining. This is because the position of the nitro group on carbon 5 of the furan ring makes these compounds toxic. Such products are furazolidone, (FUROBAC) and nitro furfural, but also include other products. (FUROBAChttp: / / terra.com.mx / -rcamacho / ges / ges-furo.html), Environmental Mutagenesis, 1983, Vol. 5: 745-765, Corn.Reg.19.03.92 ( L73), Corn. Reg. 15.10.93 (L264). [0003] It was reported earlier that 2-(2-nitrovinyl)-furan in the form of a chemical entity is still a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D307/38A61K31/341A61P33/02C07B61/00C07D307/70
CPCC07D307/70A61P33/02
Inventor E·E·奥拉扎贝尔曼索N·R·卡斯塔尼杜坎西奥T·E·盖坦普拉瑟雷斯Z·罗德里格斯奈格林H·Z·瑟拉诺佩雷兹M·I·迪亚兹莫里纳A·M·卡尔沃阿隆索O·冈萨雷斯赫南德斯
Owner CENT DE BIOACTIVOS QUIMICOS CBQ
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