Preparation of hydrobromic acid dextro methaphen and beta cyclodeatrin compounding object

A technology of dextromethorphan hydrobromide and cyclodextrin, which is applied to medical preparations containing active ingredients, pill delivery, drug combination, etc., can solve problems such as poor absorption, complicated process, and difficulty in taking medicine, and achieve rapid cough relief, Stable drug effect and good absorption effect

Inactive Publication Date: 2005-03-09
HARBIN KEDI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are many antitussive drugs, such as the United States Pharmacopoeia USP23 edition, the British Pharmacopoeia BP93 edition, and the Japanese Pharmacopoeia Prescription JB12 Corrected Edition, etc., have detailed reports, and the process of the above method is relatively complicated.
The disintegration of the drug is unstable, the absorption is poor, the bioavailability is not high, especially the taste is not good, and it is difficult to take the medicine

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Inclusion compound containing dextromethorphan hydrobromide

[0012] 1. Grind glucose, sucrose, and citric acid respectively and pass through a 100-mesh sieve. Soak hydroxypropyl cellulose in appropriate amount of water for 24 hours before use to make an 8% slurry.

[0013] 2. Dissolve dextromethorphan hydrobromide in an appropriate amount of warm water, add to β-cyclodextrin, mix and stir for 4 hours, then spray dry.

[0014] 3. After dissolving tartrazine with a small amount of hot water, add hypromellose pulp to make a 5% slurry.

[0015] 4. Mix β-cyclodextrin inclusion compound with glucose, sucrose, and citric acid powder evenly, make soft material with 5% hydroxypropylmethylcellulose (containing pigment), granulate, dry, and add stearic acid Magnesium, evenly sprayed into orange fragrance and closed for 2 hours, after sampling and testing passed, compressed into tablets.

Embodiment 2

[0017] Inclusion compound containing dextromethorphan hydrobromide

[0018] Dextromethorphan Hydrobromide Beta-Cyclodextrin 138g

[0019] Glucose 250g

[0020] Citric acid 10g

[0021] Sucrose 150g

[0022] Lemon Yellow 0.075g

[0023] Orange flavor 2g

[0024] Hydroxypropyl methylcellulose 0.01g

[0025] Magnesium Stearate 7g

Embodiment 3

[0027] Inclusion compound containing dextromethorphan hydrobromide

[0028] Dextromethorphan Hydrobromide Beta-Cyclodextrin 50g

[0029] Glucose 85g

[0030] Citric acid 3.3g

[0031] Sucrose 50g

[0032] Lemon Yellow 0.025g

[0033] Orange flavor 0.7g

[0034] Hydroxypropyl methylcellulose 0.02g

[0035] Magnesium Stearate 2.3g

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PUM

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Abstract

A medicine in the form of chewing tablet or buccal lozenge is the match of dextromethorphan hydrobromide and beta-cyclodextrin. It is a pectoral absorbing rate up to 98%.

Description

Technical field [0001] The invention relates to a pharmaceutical complex containing dextromethorphan hydrobromide. Background technique [0002] Dextromethorphan hydrobromide is a synthetic non-opioid central antitussive drug. This product has the same efficacy as codeine, and like codeine, it also acts on the central nervous system to increase cough threshold. Dextromethorphan is the safest cough suppressant available. Most of the antitussive preparations (western medicines) that can be purchased without a prescription on the market contain this ingredient. The drug is an essential drug (category B) included in the national essential drug list of our country. At present, there are many antitussive medicines, such as the United States Pharmacopoeia USP23 edition, British Pharmacopoeia BP93 edition and Japanese Pharmacopoeia Prescription JB 12 revised edition, etc., all have detailed reports, and the process of the above method is relatively complicated. The disintegration...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/403A61P11/14
Inventor 吕宝光朱沂
Owner HARBIN KEDI PHARMA
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