Cornea middle term preserving fluid

Abstract

Disclosed is a cornea middle term preserving fluid which comprises RPMI 1640 culture liquid, chondroitin sulfate, hyaluronic acid, HEPES cushioning liquid, dexamethasone, low-molecular-weight seaweed polysaccharides, Tobramycin or vancomycin, the preserving fluid has stabilized cell activity during storage period, and higher endothelial cell metabolizing function can be maintained than the US's Opthiol.

Description

technical field [0001] The invention relates to an improvement of an ophthalmic medical product, in particular to a medium-term corneal preservation solution. It belongs to the technical field of chemical composition. Background technique [0002] Among the corneal activity preservation methods in the prior art: there is the traditional wet room preservation method, which is simple and easy to implement, but the disadvantage is that the cornea preservation time is too short (only 2 days). Patent document CN1262866A discloses a corneal activity preservation solution, which includes MEM cell culture medium, chondroitin sulfate, low molecular weight dextran, dexamethasone, antibiotics and HEEPES solution. Although the preservation solution has a good preservation effect, some components may be negatively charged due to the high content of chondroitin sulfate, and strong negative charges are harmful to corneal endothelial cells. There is also a corneal preservation solution co...

AI Technical Summary

Problems solved by technology

Although the epithelial cell layer of the corneal graft is not as important as the endothelial cell layer, once the epithelial cells of the corneal graft fall off, the corneal graft is likely to edema, which not only affects the preservation quality of the corneal endothelial cell layer, but also affects the effect of corneal transplantation

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