Cornea middle term preserving fluid

A technology for preserving liquid and cornea, applied in the improvement of ophthalmic medical products and the field of mid-term corneal preservation liquid, can solve the problems of corneal graft edema, affecting the preservation quality of corneal endothelial cell layer, affecting the effect of corneal transplantation operation, etc. The effect of osmotic pressure, reduced dosage, and simple ingredients

Active Publication Date: 2005-06-29
SHENZHEN WATSIN GENETECH
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Problems solved by technology

Although the epithelial cell layer of the corneal graft is not as important as the endothelial cell layer, once the epithelial cells of the corneal graft fall off, the cor

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  • Cornea middle term preserving fluid

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Embodiment Construction

[0015] In order to clearly illustrate the technical solution of the medium-term corneal preservation solution of the present invention, it is now described in detail through the table of specific examples. Examples of the present invention are shown in Table 1.

[0016] Table 1 The formula of medium-term preservation solution of cornea:

[0017]

[0018] The medium-term preservation solution of cornea of ​​the present invention is used for the research of cat corneal epithelial shedding time:

[0019] 10 cat corneas kept in each solution for 5 days, 7 days and 15 days respectively were subjected to penetrating keratoplasty, and the survival of corneal graft epithelium at different time after operation was observed. It was found that the survival time of epithelial cells in Optisol preservation solution was maintained at 4-6 days. However, the survival time of corneal graft epithelial cells preserved in the corneal preservation solution of the present invention exceeds 7 d...

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PUM

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Abstract

Disclosed is a cornea middle term preserving fluid which comprises RPMI 1640 culture liquid, chondroitin sulfate, hyaluronic acid, HEPES cushioning liquid, dexamethasone, low-molecular-weight seaweed polysaccharides, Tobramycin or vancomycin, the preserving fluid has stabilized cell activity during storage period, and higher endothelial cell metabolizing function can be maintained than the US's Opthiol.

Description

technical field [0001] The invention relates to an improvement of an ophthalmic medical product, in particular to a medium-term corneal preservation solution. It belongs to the technical field of chemical composition. Background technique [0002] Among the corneal activity preservation methods in the prior art: there is the traditional wet room preservation method, which is simple and easy to implement, but the disadvantage is that the cornea preservation time is too short (only 2 days). Patent document CN1262866A discloses a corneal activity preservation solution, which includes MEM cell culture medium, chondroitin sulfate, low molecular weight dextran, dexamethasone, antibiotics and HEEPES solution. Although the preservation solution has a good preservation effect, some components may be negatively charged due to the high content of chondroitin sulfate, and strong negative charges are harmful to corneal endothelial cells. There is also a corneal preservation solution co...

Claims

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Application Information

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IPC IPC(8): A01N1/02
Inventor 董晓光谢立信史伟云
Owner SHENZHEN WATSIN GENETECH
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