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Injectio of troxetutin and proxyphylline and its preparing process

A technology of rutin hyprophylline and dihyprophylline, which is applied in directions such as pharmaceutical formulations, cardiovascular system diseases, powder delivery, etc., can solve problems such as inapplicability to patients in the acute onset period, and achieves easy promotion, product safety, and the like. The effect of low product cost

Inactive Publication Date: 2005-07-06
崔晓廷
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, oral drugs are not suitable for patients with acute onset

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0006] Embodiment 1: Troxerutin Prophylline Injection

[0007] Prescription: 270 grams of troxerutin, 360 grams of dihydroxyphylline, 15 grams of coumarin, appropriate amount of water for injection, total 5000ML, made into 1000 sticks.

[0008] Preparation process: Weigh 270 grams of troxerutin, 360 grams of dihydroxyprophylline, and 15 grams of coumarin, mix the three raw materials, add an appropriate amount of sterilized aqueous solution, add an appropriate amount of activated carbon, heat and boil for 30 minutes, filter After removing carbon, add sterilized aqueous solution to 5000ML, adjust the pH value to 4.5-6.5 with hydrochloric acid, fill it, and sterilize it by autoclaving at 115°C for 30 minutes.

Embodiment 2

[0009] Embodiment Two: Troxerutin Prophylline Injection

[0010] Prescription: 90 grams of troxerutin, 120 grams of dihydroxyphylline, 5 grams of coumarin, appropriate amount of water for injection, the total amount is 2000ML, made into 1000 tubes.

[0011] Preparation process: Weigh 90 grams of troxerutin, 120 grams of dihydroxyprophylline, and 5 grams of coumarin, mix the three raw materials, add an appropriate amount of sterilized aqueous solution, add an appropriate amount of activated carbon, heat and boil for 30 minutes, filter After removing carbon, add sterilized aqueous solution to 2000ML, adjust the pH value to 4.5-6.5 with hydrochloric acid, fill it, and sterilize it by autoclaving at 115°C for 30 minutes.

Embodiment 3

[0012] Example 3: Troxerutin Prophylline Infusion

[0013] Prescription: 270 grams of troxelucil, 360 grams of dihydroxyprophylline, 15 grams of coumarin, appropriate amount of water for injection, total 100000ML. Make 1000 bottles.

[0014] Preparation process: Weigh 270 grams of troxerutin, 360 grams of dihydroxyprophylline, and 15 grams of coumarin, mix the three raw materials, add an appropriate amount of sterilized aqueous solution, add an appropriate amount of activated carbon, heat and boil for 30 minutes, filter After removing carbon, add sterilized aqueous solution to 250000ML, adjust the pH value to 4.5-6.5 with hydrochloric acid, fill it, and sterilize it by hot pressing at 115°C for 30 minutes.

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PUM

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Abstract

The invention provides a Troxerutin and Diprophylline injection, transfusion, freeze-dried powder, asepsis powder for injection and its preparation, which is prepared from Troxerutin, diprophylline, and coumarin by the proportion ratio of 1-99 : 99-1, and can be used for treating diseases of ischemia cerebrovascular and brain artery hardening.

Description

Technical field: [0001] The invention provides a compound injection for ischemic cerebrovascular and cerebral arteriosclerosis diseases and a preparation method thereof. More specifically, it relates to troxerutin prophylline injection and a preparation method thereof, and belongs to the technical field of medicines and the preparation method thereof. Background technique: [0002] Ischemic cerebrovascular disease and cerebral arteriosclerosis are common diseases with a high incidence rate and are a major killer that endanger human life. For the treatment of such diseases, a single drug or a combination of several single drugs is often used, which is ineffective and troublesome in clinical use. The compound oral medicine prepared with troxerutin, dihydroxyprophylline and coumarin has been clinically applied with good effect. However, oral drugs are not suitable for patients with acute onset. The invention provides an injection prepared by using troxerutin, diprophylline a...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K9/14A61K9/19A61K31/522A61P9/10
Inventor 崔晓廷
Owner 崔晓廷
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