Compound aspirin red yeast extract medicinal preparation and its application

A technology of aspirin and extract, applied in the field of compound pharmaceutical composition, can solve the problems of unsatisfactory curative effect and the like

Inactive Publication Date: 2005-08-10
FUKANGREN BIO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] At present, clinically, it is mainly aimed at anti-thrombotic, or simply lowering blood lipids, and the curative effect is not ideal.

Method used

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  • Compound aspirin red yeast extract medicinal preparation and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Embodiment 1: prepare common sheet

[0056] Element

[0057] Preparation method: pass through 80-mesh sieve respectively for the drug and auxiliary materials, mix aspirin, red yeast rice extract, aluminum glyoxate, heavy magnesium carbonate, microcrystalline cellulose, hydroxypropyl cellulose, sodium carboxymethyl starch, talcum powder, and mix Uniform, the powder is directly compressed into tablets.

Embodiment 2

[0058] Embodiment 2: Preparation of enteric-coated tablets

[0059] According to Example 1, 1000 ordinary compound aspirin tablets were prepared and coated with an enteric coating material.

[0060] prescription:

[0061] 1000 tablets

[0062] Hydroxypropyl Methyl Cellulose Phthalate 37.5g Coating Polymer

[0063] Ethylcellulose 6.1g Film coating aid

[0064] Ethanol 225ml organic solvent

[0065] Acetone 225ml organic solvent

[0066] Coating with a coating pan

[0067] Operating conditions:

[0068] Coating pan speed 6~7r / min

[0069] Spray Type Airless Spray

[0070] Nozzle size 0.4mm nozzle (60° angle)

[0071] Spray rate 110mL / min

[0072] Liquid pressure 60~80kg / cm 2

[0073] Exhaust velocity 140~160m 3 / min

[0074] Intake air velocity 130~150m 3 / min; 20℃

[0075] 40%~60% relative humidity

[0076] Coating time 30min

[0077] Tablet weight increased by 5% after coating.

Embodiment 3

[0079] Preparation of Compound Aspirin Capsules

[0080] Element

Quantity % (mg / mg)

Quantity / grain (mg)

aspirin

8.0

40.0

Red Yeast Extract

60.0

300.0

Aluminum glycylate

1.2

6.0

Heavy Magnesium Carbonate

2.2

11.0

microcrystalline cellulose

23.1

115.5

povidone

1.5

7.5

Croscarmellose

4.0

20.0

Total

about 100%

about 500mg

[0081] Capsule shell ------ ------

[0082] Preparation method: pass through 80-mesh sieve respectively for the drug and auxiliary materials, mix aspirin, red yeast extract, aluminum glyoxate, heavy magnesium carbonate, microcrystalline cellulose, and cross-linked carboxymethyl cellulose, and mix them with 5% polystyrene Vitone 95 ethanol solution is made of soft materials, sieved, dried, granulated, and packed into capsule shells.

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Abstract

A compound medicine contains aspirin, extract of red rice, dihydroxyaluminium aminoacetate, heavy magnesium carbonate or magnesium aluminate carbonate, and medical auxiliary. Its application is also disclosed.

Description

Technical field: [0001] The present invention relates to a compound pharmaceutical composition, in particular to a pharmaceutical composition containing 5mg-100mg of aspirin and 10-1000mg of red yeast rice extract. 44mg, or aluminum magnesium carbonate 15-150mg, and appropriate amount of pharmaceutically acceptable excipients. Background technique: [0002] Small doses of aspirin can inhibit the platelet release response (release caused by adrenaline, collagen, thrombin, etc.) and aggregation reaction (second phase aggregation). It can prolong bleeding time and reduce thrombus formation in vivo. Simultaneous inhibition of cholesterol biosynthesis reduces normal and elevated low-density lipoprotein cholesterol (LDL-C) levels. [0003] As a traditional Chinese medicine, red yeast rice is recorded in "Pharmacopoeia of the People's Republic of China" and "Dictionary of Chinese Medicine". Description Red koji, also known as red koji, is prepared by inoculating Monascus on rice...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61P3/06A61P7/02
Inventor鄂滟蔡金巧
OwnerFUKANGREN BIO PHARMA