Method and application of producing disease model of local cerebral ischemia by using macaque

A disease model and cerebral ischemia technology, applied in the field of medical and life science experimental research, can solve problems such as cerebrospinal fluid leakage, vasospasm, and influence on vascular recanalization, and achieve the effect of ensuring integrity, easy operation, and reduced dosage

Inactive Publication Date: 2005-08-31
高焕民 +1
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  • Abstract
  • Description
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  • Application Information

AI Technical Summary

Problems solved by technology

[0006] 1. Requires delicate intraorbital manipulation
[0007] 2. Damage to the neural network on the middle cerebral artery
[0008] 3. Since the cranial cavity has been opened, resulting in cerebrospinal fluid leakage
[0009] 4. Since the operation is performed in a deep cavity, in order to clamp the middle cerebral artery with instruments such as vascular clips, when the middle cerebral artery is separated, the arachnoid around the blood vessel is damaged, so it is easy to cause bleeding, which leads to vasospasm and affects the blood vessels. recanalization
[0010] 5. It is impossible to ensure the stability of the blood flow in the blood vessels, the condition of the collateral circulation and the control of the size of the infarct.
Therefore, the temporal and spatial variation of the local circulation of the brain makes it difficult to treat the infarct lesions statistically, and it is difficult to evaluate the effects of drugs and other treatments.

Method used

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  • Method and application of producing disease model of local cerebral ischemia by using macaque
  • Method and application of producing disease model of local cerebral ischemia by using macaque
  • Method and application of producing disease model of local cerebral ischemia by using macaque

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specific Embodiment approach

[0052] The experimental animal macaque (Macaca mulatta), also known as yellow monkey, rhesus monkey, and Guangxi monkey, belongs to the monkey family; it is divided into an experimental group (8 cases) and a control group (or "sham operation group", 5 cases), each group according to Experiments require different repetitions. Details are as follows:

[0053] 13 experimental rhesus monkeys, male or female, 3-4.5 years old (equivalent to juveniles, female animals have no menstruation, so the influence of hormones and sexual cycle can be ruled out), body weight 4.35±0.23Kg. Provided by the monkey room of the Shanghai Institute of Physiology, Chinese Academy of Sciences, it has been confirmed to be free of infectious diseases through quarantine and can be used for experiments.

[0054] When catching, use the net catch method, open the left and right movable sliding doors on the front of the monkey cage for about 5cm, and extend the self-made monkey net (net opening 30×28cm, mesh 4...

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Abstract

A focal cerebroischemia model for researching and treating human cerebral thrombus is created through providing a macaca mulatta, and introdicing a microspherical catheter to block the start position of cerebral artery.

Description

technical field [0001] The invention belongs to the field of medical and life science experimental research, and in particular relates to a method for manufacturing a primate focal cerebral ischemic disease model. [0002] This design overcomes the shortcomings of the traditional primate cerebral ischemia method that the ischemia time and degree cannot be controlled. The design is reasonable and novel, and it is easy to promote and use in hospitals and scientific research departments. Model, so as to explore the pathogenesis and study the therapeutic effect. Background technique [0003] The mechanism of cerebral ischemia has been studied for nearly a hundred years, and it is still one of the important research topics in neuroscience. Due to the limitation of experimental conditions, in the past, the experimental subjects of cerebral ischemia were generally limited to rats, rabbits and other animals, and there were relatively few primates, bu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/00
Inventor 高焕民梁桂霞柳耀泉王少萍相波
Owner 高焕民
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