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Compound Tramadol Hydrochoride dispersible Tablet

A technology of compound tramadol hydrochloride and tramadol hydrochloride, applied in pill delivery, neurological diseases, drug combination, etc.

Inactive Publication Date: 2005-09-14
黄本东
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] There is currently no research on compound tramadol hydrochloride dispersible tablets

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0020] According to the preparation method disclosed in the description, the present invention has prepared a formula as shown in Table 1. The specific excipients and dosage are shown in Table 1. See Table 1 for the results of detecting its dispersibility according to the method of Chinese Pharmacopoeia (2000 edition).

[0021] The results show that the compound tramadol hydrochloride dispersible tablet provided by the invention meets the regulations of the Chinese Pharmacopoeia (2000 edition) about dispersible tablets.

[0022] Raw materials

[0023] Raw materials

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PUM

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Abstract

The invention relates to one agent type of compound tramadol hydrochloride. The provided technical project produces tramadol hydrochloride and acetyltropolone dispersible tablet with following components in weight fractions: tramadol hydrochloride in 37.5 deals; acetyltropolone in 325 deals; filling agent in 15-25 deals selected from lactose, compressible starch, white dextrine and / or starch; disintegrating adminicle in 50-70 deals selected from crosslinked polyvinyl pyrrolidone, microcrystalline cellulose, L-HPC, sodium carboxymethylstarch and / or compressible starch; lubricating agent in 1-2.5 deals selected from magnesium or / and talcum powder. The time of dispersing uniformly of provided dispersible tablet can reach 1 minutes and the time limit of disintegrating can reach 2 minutes.

Description

technical field [0001] The invention relates to a dosage form of tramadol hydrochloride compound preparation. technical background [0002] Tramadol is a centrally acting analgesic for moderate to severe pain. Since its launch in Germany in 1977, it has now entered many countries. Although the drug is widely used clinically, epidemiological data show that tramadol has not become a drug of abuse. The low addiction of tramadol has been further confirmed in animal experiments. Given the low abuse potential of tramadol, the prescription of tramadol in Germany is not subject to narcotics control conditions. Acetaminophen is an acetanilide antipyretic and analgesic drug, which can be absorbed quickly and completely when taken orally. Its effect is similar to that of aspirin, but its analgesic effect is weak, and it has little stimulation to the gastrointestinal tract. No harm, it is a relatively safe and effective antipyretic and analgesic drug, and it is also the most commonly...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/137A61K31/167A61P25/04
Inventor 雷良平覃琳
Owner 黄本东
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