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Chinese medicine freeze-dried powder injection for anti-tumour and its preparing method

A freeze-dried powder injection, anti-tumor technology, applied in anti-tumor drugs, freeze-dried delivery, pharmaceutical formulations, etc., can solve the problems of poor drug stability, many adverse reactions, improper medication, etc. Comprehensive, inclusive and efficient effects

Inactive Publication Date: 2005-10-19
张海峰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, since the injection contains two highly toxic drugs, mylabris and toad venom, and the active ingredients contained in the two are also toxic ingredients, there are many adverse reactions during use. and the urinary system are also affected, and improper medication may even cause death; the preparation process of the injection is astragalus and mylabris are extracted and refined by the lithothiol method, because the liquid treated by the lithothiol method has a relatively high inorganic salt content, the injection made Pain often occurs, which also increases the irritation of the injection to muscles and blood vessels
In addition, due to the strong volatility of cantharidin and the poor stability of bufotoxin, these factors make the quality of the preparation difficult to control; at the same time, because it is an injection, it is inconvenient to carry and use, and it is easily contaminated. Precipitation occurs, transportation is inconvenient, and the preparation method is relatively complicated, which limit its further clinical application

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] (1) Composition of raw materials: ginseng 100g, astragalus 300g, toad venom 2g, mylabris 10g.

[0052] (2) Get ginseng and astragalus, add 6 times of 50% ethanol to reflux and extract three times, each reflux time is 2 hours, ethanol reflux liquid is decompressed and reclaimed ethanol and concentrated, the concentrated solution is diluted with 4 times of water, stirred evenly, statically Set, filtered, and the filtrate was concentrated under reduced pressure and dried to obtain dry extract A.

[0053] (3) Take ginseng and astragalus dregs, decoct three times with 6 times the amount of water, boil for 1 hour each time, combine three decoctions, concentrate under reduced pressure, add ethanol to make the alcohol content reach 60%, filter, precipitate and add water Dissolve, centrifuge, concentrate the centrifugate under reduced pressure, add ethanol to make the alcohol content reach 80%, let it stand at low temperature overnight, pour out the supernatant, add ethanol to t...

Embodiment 2

[0059] (1) Composition of raw materials: ginseng 100g, astragalus 300g, toad venom 2g, mylabris 10g.

[0060] (2) Get ginseng and Radix Astragali, add 6 times the amount of 40% ethanol to reflux and extract three times, each reflux time is 2.5 hours, the ethanol reflux liquid is decompressed to recover ethanol and concentrate, the concentrated solution is diluted with 6 times the amount of water, stirred evenly, Stand still, filter, and the filtrate is concentrated under reduced pressure and dried to obtain dry extract A.

[0061] (3) Take ginseng and astragalus dregs, decoct three times with 6 times the amount of water, boil for 1 hour each time, combine three decoctions, concentrate under reduced pressure, add ethanol to make the alcohol content reach 60%, filter, precipitate and add water Dissolve, centrifuge, concentrate the centrifugate under reduced pressure, add ethanol to make the alcohol content reach 80%, let it stand at low temperature overnight, pour out the supern...

Embodiment 3

[0067] (1) Composition of raw materials: ginseng 100g, astragalus 300g, toad venom 2g, mylabris 10g.

[0068] (2) Get ginseng and astragalus, add 6 times of 30% ethanol to reflux and extract three times, each reflux time is 3 hours, and the ethanol reflux liquid is decompressed to reclaim ethanol and concentrate, and the concentrated solution is diluted with 8 times of water, stirred evenly, and statically Set, filtered, and the filtrate was concentrated under reduced pressure and dried to obtain dry extract A.

[0069] (3) Take ginseng and astragalus dregs, decoct three times with 6 times the amount of water, boil for 1 hour each time, combine three decoctions, concentrate under reduced pressure, add ethanol to make the alcohol content reach 60%, filter, precipitate and add water Dissolve, centrifuge, concentrate the centrifugate under reduced pressure, add ethanol to make the alcohol content reach 80%, let it stand at low temperature overnight, pour out the supernatant, add ...

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Abstract

The present invention discloses a kind of freeze dried antitumor Chinese medicine powder for injection and its preparation process. The freeze dried antitumor Chinese medicine powder for injection is prepared with ginseng and astragalus root extract, cantharides and toad cake extract inclusion, and medicinal supplementary material. The ginseng and astragalus root extract is obtained through first alcohol extraction and then water extraction; and the cantharides and toad cake extract inclusion is obtained through extracting cantharides and toad cake to obtain extract and including the extract with hydroxypropyl-beta-cyclodextrin. The preparation of the present invention has high stability, and less irritation and toxic side effect, and pharmacological test shows that the preparation has excellent treating effect.

Description

Technical field [0001] The invention belongs to the technical field of traditional Chinese medicine pharmacy, and particularly relates to an anti-tumor traditional Chinese medicine freeze-dried powder injection and a preparation method thereof. Background technique [0002] Tumor diseases seriously threaten the health of human beings. It is not only a huge medical problem, but also a huge social problem. Due to the high incidence of tumor diseases and the ferocious approach, there are generally no particularly effective therapeutic drugs and methods; in the prior art Western medicine combined with radiotherapy and chemotherapy is used to treat such diseases. Due to the large side effects of Western medicine, the patient's body is unbearable. One of the characteristics of malignant tumors is that tumor cells are easy to spread and easy to recur after surgery. The reason why tumors are refractory is that Not irrelevant. At present, great progress has been made in the applicat...

Claims

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Application Information

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IPC IPC(8): A61K9/19A61P35/00
Inventor 张海峰
Owner 张海峰
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