Single-chamber, double-layered osmosis pump control-release system with holes on two sides

Abstract

A single-chamber dual-layer osmotic-pumping release controlling system perforated on both surfaces for the oral taking of the medicine difficult to dissolve is composed of a core body consisting of a drive-assistant layer and a medicine-contained layer, and the coated layer with orifices on both surfaces.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular it is a double-sided perforated single-chamber double-layer osmotic pump controlled release system. The single-chamber double-layer osmotic pump controlled-release system includes a core body composed of a booster layer and a drug-containing layer containing pharmacologically active substances. A small hole is punched in each coating film. Background technique [0002] The purpose of the single-chamber double-layer osmotic pump controlled release system is to release the poorly soluble drug at a release rate close to zero order, so as to reduce and delay the peak plasma concentration of the drug without affecting the drug supply. Undesirable side effects can be reduced due to lower peak plasma concentrations. At the same time, since the peak concentration of the plasma drug is delayed and the time of the plasma drug concentration above the therapeutic concentration is prolonged, ...

AI Technical Summary

Problems solved by technology

The pigment itself has no pharmacological effect. The addition of the pigment not only increases the production cost, but also makes the production process more cumbersome. More importantly, because the coating material of the osmotic pump controlled release system is usually cellulose acetate or ethyl cellulose, etc. Cellulosic substances, the coating film will turn white during the drying process before punching, which largely hides the color of the tablet core, so even if pigments are used, there is still a high rate of misprinting

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