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High performance liquid chromatography-hydride atomic absorption / fluorescence spectrum instruments interface

A high-performance liquid chromatography and atomic absorption technology, which is applied in the field of analytical chemistry instrument interface design, can solve the problems of reducing chromatographic separation efficiency and achieve the effect of peak broadening

Inactive Publication Date: 2005-11-23
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In order to achieve high efficiency of on-line digestion, an on-line digestion pipeline up to 5 meters is generally used, but due to the serious post-column broadening caused by the long pipeline, the efficiency of chromatographic separation is greatly reduced

Method used

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  • High performance liquid chromatography-hydride atomic absorption / fluorescence spectrum instruments interface
  • High performance liquid chromatography-hydride atomic absorption / fluorescence spectrum instruments interface

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Such as figure 1 Shown, the present invention mainly comprises: thin internal diameter tee (2), thin quartz tube (4), ultraviolet lamp (5), four-way (6), reaction tube (9), large internal diameter tee (12) and connecting Tube. The connection mode is: the thin inner diameter tee (2) is connected with the fine quartz tube (4), the cross (6), the reaction tube (9) and the large inner diameter tee (12) successively. The thin inner diameter tee (2) branch pipe connects the high performance liquid chromatography effluent inlet (1) and K 2 S 2 o 3 (1.5%) (as an oxidizing agent, other persulfates can also be used) solution delivery pipe (3). Two thin quartz tubes (4) (inner diameter: 0.5mm, length: 20cm) are connected with connecting pipelines (14), and are close to the outer wall of the ultraviolet lamp tube (5) (ultraviolet lamp power: 5W). Four-way connection hydrochloric acid solution (30%) (acid solution, reacts with reducing agent to generate active hydrogen, reduces...

Embodiment 2

[0020] Connection mode is the same as embodiment 1,

[0021] Two thin quartz tubes (4), inner diameter: 1.5mm, length: 40cm;

[0022] UV lamp power: 15W;

[0023] Reaction tube (9): inner diameter 0.5mm, length 60cm;

[0024] Fine inner diameter tee (2): inner diameter 1.2mm;

[0025] Four-way (6): inner diameter 1.5mm;

[0026] Large inner diameter tee (12): inner diameter 2.5mm;

[0027] K 2 S 2 o 3 Solution pump flow: 0.5ml / min;

[0028] Hydrochloric acid solution pump flow rate: 0.5ml / min;

[0029] KBH 4 Solution pump flow rate: 0.5ml / min.

[0030]After the analyte is separated by high performance liquid chromatography, it passes through the thin inner diameter tee (2) and the K 2 S 2 o 3 The solution is mixed into the UV digestion section (thin quartz tube (4)), where it digests under the action of UV light to produce small molecules that are prone to hydrides. The digested product was mixed with hydrochloric acid solution and KBH 4 The solutions are mixed ...

Embodiment 3

[0032] Connection mode is the same as embodiment 1,

[0033] Two thin quartz tubes (4), inner diameter: 2mm, length: 10cm;

[0034] UV lamp power: 8W;

[0035] Reaction tube (9): 2mm, length 40cm;

[0036] Fine inner diameter tee (2): inner diameter 1mm;

[0037] Four-way (6): inner diameter 2mm;

[0038] Large inner diameter tee (12): inner diameter 2mm;

[0039] K 2 S 2 o 3 Solution pumping flow: 2ml / min;

[0040] Hydrochloric acid solution pump flow rate: 2.5ml / min;

[0041] KBH 4 Solution pump flow: 2.5ml / min.

[0042] After the analyte is separated by high performance liquid chromatography, it passes through the thin inner diameter tee (2) and the K 2 S 2 o 3 The solution is mixed into the UV digestion section (thin quartz tube (4)), where it digests under the action of UV light to produce small molecules that are prone to hydrides. The digested product was mixed with hydrochloric acid solution and KBH 4 The solutions are mixed to form hydrides, which enter...

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Abstract

The invention relates to an effective liquid chromatograph-hydride atom absorption / fluorescence spectrum instrument interface in the field of analytical chemistry joint instrument interface designing technique. It has the following characters: it contains connected slim inner diameter three-bit byte, slim quartz tube, four-way connection, reaction tube and big inner diameter three-bit byte, wherein first tube of slim inner diameter three-bit byte is connected with effluent liquid entrance of effective liquid chromatograph; second tube is connected with oxidant spread tube; the third tube in connected with one end of slim quartz tube which in near a UV lamp tube; the other end of slim quartz tube is connected with first tube of four-way connection, second tube of four-way connection is connected with acid solution spread tube, the third tube is connected with reducer spread tube, the forth tube is connected with one end of reaction tube, while the other end is connected with first tube of big inner diameter three-bit byte, second tube in connected with addendum, the third tube is connected with spread tube which is to gas-liquid divider.

Description

Technical field: [0001] The invention relates to the technical field of interface design for analytical chemistry combined instruments, in particular to the interface design for combined use of chromatography and electrothermal atomic absorption / atomic fluorescence instruments. Background technique: [0002] The toxicity, bioavailability, and mobility of elements are largely determined by their existing forms. Speciation analysis can provide more information than total element concentration analysis. It can not only reflect the content of the analyte, but also reflect The existence state of the analyte is of great significance to the research of environmental science and life science, and has attracted enough attention. The object of speciation analysis is usually biological or environmental samples. Generally speaking, the sample matrix is ​​relatively complex, and the content of elements to be measured is trace level. In addition, each form must be qualitatively and quanti...

Claims

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Application Information

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IPC IPC(8): G01N35/00
Inventor 张新荣朱振利赵蕊韦超邢志刘华琳
Owner TSINGHUA UNIV
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