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Lyophilized powder injection for treating ischemic cardio-cerebrovascular diseases and its preparing method

A technology for cardiovascular and cerebrovascular diseases and freeze-dried powder injection, which is applied in the field of preparation of traditional Chinese medicines, can solve problems such as preparations for cardiovascular and cerebrovascular diseases that have not been seen on the market, and achieves easy control of product quality, vasodilation, efficacy and safety. high sex effect

Active Publication Date: 2010-04-28
SHANXI BUCHANG PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

my country is the country with the richest ginkgo leaf resources, accounting for more than 70% of the world's total. Although there are many varieties of ginkgo leaf extract preparations, so far in various open documents, there has not been any Ginkgo biloba extract as the main preparation. Related reports on the marketing of pharmaceutical raw materials for the treatment of ischemic cardiovascular and cerebrovascular diseases

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0126] Preparation of Ginkgo biloba extract: Take 1 kg of dry green Ginkgo biloba coarse powder, extract 3 times with 8 times the amount of 60% ethanol under reflux, each time for 1.5 hours, combine the extracts, filter, reclaim the ethanol from the filtrate, add methionine to stir and dissolve, and use Citric acid was used to adjust the pH value to 4-5, concentrated to liquid extract (1:1.5), filtered, the filtrate was concentrated to (1:5.5), extracted 3 times with n-hexane, and the extracted aqueous phase was extracted with ethyl acetate for 4 times, and then extracted 6 times with water-saturated sec-butanol-ethyl acetate, combined all extracts, recovered ethyl acetate and sec-butanol under reduced pressure at about 50°C and 80°C, respectively, evaporated to remove residual ester and residual alcohol, Polyamide chromatography, eluting with 1000 ml of 60% ethanol, combining the eluents, recovering ethanol, concentrating to near dryness, and vacuum drying at 70°C to obtain th...

Embodiment 2

[0128] Example 2 of product preparation: Take about 1600ml of water for injection and put it in a concentrated preparation container, add about 165g of mannitol, heat and stir to dissolve, adjust the pH to 4-5 with 10% citric acid solution, add 0.2% activated carbon for 15 minutes, filter To clarify, add 20g of Ginkgo biloba extract to the filtrate, stir to dissolve, filter to clarify with a composite micromembrane filter, add water for injection to 1800ml, fine filter with a stainless steel micromembrane terminal filter to clarify, aseptically subpackage, pre-freeze, freeze-dry, seal, Promptly get 1000 bottles of freeze-dried powder for injection.

Embodiment 3

[0129] Example 3 of product preparation: Take about 1600ml of water for injection and put it in a concentrated preparation container, add about 165g of mannitol, heat and stir to dissolve, adjust the pH to 4-5 with 10% citric acid solution, add 0.2% activated carbon for 15 minutes, filter To clarify, add 55g of Ginkgo biloba extract to the filtrate, stir to dissolve, filter to clarify with a composite micromembrane filter, add water for injection to 1800ml, fine filter with a stainless steel micromembrane terminal filter to clarify, aseptically subpackage, pre-freeze, freeze-dry, seal, Promptly get 1000 bottles of freeze-dried powder for injection.

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Abstract

The present invention relates to a freeze-dried powder injection with the functions of expanding blood vessel and improving microcirculation for effectively curing ischemic angiocardiopathy and cerebrovascular disease, coronary heart disease, angina pectoris, cerebral embolism and cerebrovascular spasm, etc. with obvious therapeutic effect. Said freeze-dried powder injection is prepared by using ginkgo leaf extract. Besides, said invention also provides its preparation process and concrete steps.

Description

technical field [0001] The invention relates to a freeze-dried powder injection for treating ischemic cardiovascular and cerebrovascular diseases and a preparation method thereof, belonging to the technical field of preparation of traditional Chinese medicines. Background technique [0002] Coronary arteriosclerotic heart disease, angina pectoris, and brain function decline are common and frequently-occurring diseases in the elderly. According to the statistics of Beijing Anzhen Hospital, there are 2 million people in Beijing suffering from cardiovascular and cerebrovascular diseases, an average of one out of every five Beijingers. After the acute phase of the disease, the patients often leave many sequelae, such as behavioral dysfunction, cognitive impairment, etc. Cognitive barriers, etc., have brought great pain to the patients themselves and their families. With the acceleration of the aging process, the development of new drugs for anti-aging, prevention and treatment ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/16A61K9/19A61P9/10A61K127/00
Inventor 赵涛
Owner SHANXI BUCHANG PHARMA CO LTD