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Asari dripping pills and its preparation process

An asarum and phlegm-removing technology, which is applied in the directions of pill delivery, pharmaceutical formulations, and medical preparations containing active ingredients, etc., can solve the problems that are not conducive to improving the ability of patients to seek medical treatment, the overall health level of the society, and the physical harm of staff. , to achieve the effect of improving bioavailability, high bioavailability, and no dust pollution

Inactive Publication Date: 2006-01-18
COSCI MED TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0015] Although injections have the advantages of quick onset and high bioavailability, they are usually prone to allergic reactions. For example, two cases of asarone injection reported by Bo Mingxiang et al. Medical history of anaphylactic shock caused by fluid [4]
At the same time, the injection also has the disadvantages of inconvenient use, great pain for patients, and high industrial cost.
[0016] At the same time, conventional oral dosage forms often produce large dust pollution during the preparation process, which will cause harm to the health of the staff to a certain extent, and will also cause certain pollution to the environment.
In addition, the production process of conventional oral preparations is relatively complicated, and the production cost is high, so that the cost of medication for patients is also increased, which is not conducive to improving the ability of patients to seek medical treatment, and is also not conducive to improving the overall health level of society

Method used

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  • Asari dripping pills and its preparation process

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0069] Get α-asarone fine powder 100g, polyethylene glycol 6000 100g, sodium carboxymethyl starch 10g, the asarone dropping pills that adopt preceding preparation method to make, average pill weight 30mg, every ball contains α-asarone 14.3mg.

[0070] Original dosage form tablet and the comparison of drop pill dissolution rate of the present invention:

[0071] According to Chinese Pharmacopoeia 2005 Edition Appendix XC Dissolution Determination (2) method slurry method, take the original dosage form tablets, place them in cups respectively, adjust the height of the slurry to the specified position, immerse in a 1000ml beaker, use 1000ml 5% ethanol as the dissolution medium , the temperature is 37±1°C, and the paddle rotation speed is 100rpm. After a certain period of time, take samples, filter, and measure the content by UV. Calculation of dissolution.

[0072] Also use the above method to measure the dissolution rate of the dropping pills, after a certain period of time, ...

example 2

[0075] Get α-asarone fine powder 100g, polyethylene glycol 4000 200g, sodium carboxymethyl starch 30g, the asarone dropping pills that adopt preceding preparation method to make, average pill weight 40mg, every ball contains α-asarone 13.2mg.

[0076] Original dosage form tablet and the comparison of drop pill dissolution rate of the present invention:

[0077] According to Chinese Pharmacopoeia 2005 Edition Appendix XC Dissolution Determination (2) method slurry method, take the original dosage form tablets, place them in cups respectively, adjust the height of the slurry to the specified position, immerse in a 1000ml beaker, use 1000ml 5% ethanol as the dissolution medium , the temperature is 37±1°C, and the paddle rotation speed is 100rpm. After a certain period of time, take samples, filter, and measure the content by UV. Calculation of dissolution.

[0078] Also use the above method to measure the dissolution rate of the dropping pills, after a certain period of time, ...

example 3

[0081] Get α-asarone fine powder 50g, polyethylene glycol 6000 250g, sodium carboxymethyl starch 60g, the asarone dropping pills that adopt preceding preparation method to make, average pill weight 50mg, every ball contains α-asarone 6.9mg.

[0082] Original dosage form tablet and the comparison of drop pill dissolution rate of the present invention:

[0083] According to Chinese Pharmacopoeia 2005 Edition Appendix XC Dissolution Determination (2) method slurry method, take the original dosage form tablets, place them in cups respectively, adjust the height of the slurry to the specified position, immerse in a 1000ml beaker, use 1000ml 5% ethanol as the dissolution medium , the temperature is 37±1°C, and the paddle rotation speed is 100rpm. After a certain period of time, take samples, filter, and measure the content by UV. Calculation of dissolution.

[0084] Also use the above method to measure the dissolution rate of the dropping pills, after a certain period of time, ta...

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Abstract

The invention discloses an Asarone drop pill, which is a medicinal composition with the functions of antibiosis, anti-inflammation, relieving cough, removing phlegm, spasmolysis, anti-eclampsia and anti-epileptics. The drop pill has the advantages of high biological availability, quick-speed medicine release, quick-speed effect, higher medicinal content, accurate administration dosage, low price, no acute allergic reaction or adverse effect, and facilitated transportation and carrying. The drop pill is prepared from Asarone as the active component, and medicinal carrying agent as the base material.

Description

technical field [0001] The invention relates to a pharmaceutical composition for antibacterial and anti-inflammatory, cough relieving, expectorant, asthma relieving, sedative, antispasmodic, anticonvulsant, antiepileptic, etc., in particular to a drug prepared from asarone Composition Oral formulation. Background technique [0002] Asarone: also known as α-asarone and α-asarone, the English name Asarone is one of the main components of the volatile oil contained in the rhizome of the traditional Chinese medicine Shichangpu. This product is white needle crystal or crystalline powder, odorless and tasteless. Insoluble in water, soluble in ethyl acetate, chloroform, ether, soluble in ethanol, petroleum ether. [0003] Chemical name: 2,4,5-trimethoxy-1-propenylbenzene [0004] Molecular formula: C 12 h 16 o 3 [0005] Molecular weight: 208.25 [0006] Melting point: (58~595)℃ [0007] Content: 97%~100% [0008] Chemical Structure: [0009] [0010] Asarone [0011...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/882A61K9/20A61P11/14A61P11/10A61P11/06A61P25/08
Inventor 王锦刚
Owner COSCI MED TECH CO LTD
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