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New administration way of Chinese monkshood rhizome injecta and preparing technology

A technology of injection and danmu, which is applied in the field of new drug administration route and preparation technology of danmu injection, and can solve problems such as swelling and pain, injection induration, and small dosage

Inactive Publication Date: 2006-03-08
FUKANGREN BIO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, in terms of clinical application, Danmu injection adopts the intramuscular injection method, which is absorbed through the tissue at a slower rate and with a smaller dose, which not only increases the pain of the patient, but also causes local induration of the injection, even swelling and pain, and secondary infection. Frequent injections can also easily lead to "gluteal muscle contracture"
This medication method obviously limits its clinical application
Therefore, in response to this problem, we have developed an intravenous route of administration, which overcomes the shortcomings of slow absorption and long onset time

Method used

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  • New administration way of Chinese monkshood rhizome injecta and preparing technology

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Experimental program
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Effect test

Embodiment 1

[0041] The preparation method of injection of the present invention:

[0042] Take 3000g of bile wood, slice it, crush it into a coarse powder, add water and decoct three times, the first time for 2 hours, the second time for 1.5 hours, and the third time for 1 hour, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.18-1.19 (50-60°C) clear paste, add 4 times the amount of paris plaster powder, mix well, dry under reduced pressure at 70-80°C, pulverize into 50-mesh powder, add ethanol to make the alcohol content reach 85%, stir and extract three times, refrigerate , stand still for 24 hours, take the supernatant, recover ethanol, add water for injection to a relative density of 1.02-1.03 (50-60°C), cool to room temperature, adjust the pH value to 2.0-3.0 with 10% hydrochloric acid solution, refrigerate, Stand still for 24 hours, filter, adjust the pH value of the filtrate to 7.0-7.2 with 20% sodium hydroxide solution, refrigerate, stand stil...

Embodiment 2

[0044] The preparation method of sterile powder of the present invention:

[0045] Take 3000g of bile wood, slice it, crush it into a coarse powder, add water and decoct three times, the first time for 2 hours, the second time for 1.5 hours, and the third time for 1 hour, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.18-1.19 (50-60°C) clear paste, add 4 times the amount of paris plaster powder, mix well, dry under reduced pressure at 70-80°C, pulverize into 50-mesh powder, add ethanol to make the alcohol content reach 85%, stir and extract three times, refrigerate , stand still for 24 hours, take the supernatant, recover ethanol, add water for injection to a relative density of 1.02-1.03 (50-60°C), cool to room temperature, adjust the pH value to 2.0-3.0 with 10% hydrochloric acid solution, refrigerate, Stand still for 24 hours, filter, adjust the pH value of the filtrate to 7.0-7.2 with 20% sodium hydroxide solution, refrigerate, stand...

Embodiment 3

[0047] The preparation method of freeze-dried powder of the present invention:

[0048] Take 3000g of bile wood, slice it, crush it into a coarse powder, add water and decoct three times, the first time for 2 hours, the second time for 1.5 hours, and the third time for 1 hour, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.18-1.19 (50-60°C) clear paste, add 4 times the amount of paris plaster powder, mix well, dry under reduced pressure at 70-80°C, pulverize into 50-mesh powder, add ethanol to make the alcohol content reach 85%, stir and extract three times, refrigerate , stand still for 24 hours, take the supernatant, recover ethanol, add water for injection to a relative density of 1.02-1.03 (50-60°C), cool to room temperature, adjust the pH value to 2.0-3.0 with 10% hydrochloric acid solution, refrigerate, Stand still for 24 hours, filter, adjust the pH value of the filtrate to 7.0-7.2 with 20% sodium hydroxide solution, refrigerate, ...

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Abstract

The present invention relates to a Chinese medicine nauclea officinalis injection for effectively curing acute tonsillitis, acute pharyngitis, acute conjunctivitis and upper respiratory tract infection. Said invention also provides the concrete steps of its preparation method. The invented Chinese medicine nauclea officinalis injection can be used for intravenous injection.

Description

Technical field: [0001] The invention relates to a new administration route of traditional Chinese medicine injection, in particular to a new administration route of Danmu injection and a preparation process thereof. technical background: [0002] Respiratory diseases such as acute tonsillitis, acute pharyngitis, acute conjunctivitis, upper respiratory tract infection, pneumonia, and bronchitis are common and frequently-occurring diseases in clinic. Most of the pathogens that cause upper respiratory tract infection are viruses, and there is no specific drug for this at present, and general antibiotics have no obvious therapeutic effect on upper respiratory tract infection. If antibiotics are used excessively or unnecessarily, it will not only cause some toxic side effects to the human body, but also more likely to cause "flora imbalance" in the body. Traditional Chinese medicine has obvious advantages in this respect. Therefore, the independent development of traditional C...

Claims

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Application Information

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IPC IPC(8): A61K36/74A61K9/08A61K9/14A61K9/19A61P11/00A61P11/04
Inventor 刘露
Owner FUKANGREN BIO PHARMA
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