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Bioreactor system for animal large scale cell culture

A bioreactor and cell culture technology, applied in the field of bioreactor systems, can solve problems such as sawtooth fluctuations in pH and dissolved oxygen, control deviations in pH and dissolved oxygen, and unbalanced pressures, etc., to achieve high transmission power and uniform mixing , the effect of simple structure

Inactive Publication Date: 2006-05-03
EAST CHINA UNIV OF SCI & TECH
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  • Abstract
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Problems solved by technology

However, in actual operation, the respective pressures of the gases entering the reactor from the steel cylinder and the air compressor are not balanced, and this imbalance will cause one or several gases with higher pressure to be fed in excess, while other gases with lower pressure The gas cannot enter the reactor, so that the control of pH and dissolved oxygen has a large deviation; in addition, various gas flux errors caused by this pressure imbalance cannot be corrected by the PID control mode, and the result is pH and dissolved oxygen. Dissolved oxygen produces sharp jagged fluctuations

Method used

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  • Bioreactor system for animal large scale cell culture
  • Bioreactor system for animal large scale cell culture
  • Bioreactor system for animal large scale cell culture

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Embodiment Construction

[0027] see figure 1 , the bioreactor system of the present invention comprises:

[0028] A fully enclosed magnetic drive device 101 for driving the stirring shaft of the reactor;

[0029] A mixing chamber 102 connected to the reactor through pipelines;

[0030] An air supply system 103 connected to the mixing chamber 102 through pipelines;

[0031] see figure 2 , said fully enclosed magnetic transmission device includes upper bearing (1), lower bearing (6), inner magnetic transmission shaft (2), non-magnetic sealing sleeve (3), outer magnetic steel (4) and magnetic permeable cylinder ( 5), inner bearing (7), combined paddle assembly;

[0032] Said outer magnetic steel (4) is arranged outside the non-magnetic sealing sleeve (3), between the upper bearing (1) and the lower bearing (6); it is driven by an external motor as the power source of the entire stirring system;

[0033] The bottom end of said non-magnetic sealing sleeve (3) is hermetically connected with the top co...

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Abstract

The invention discloses a bioreactor system for culturing animal cell in large scale, which comprises: a reactor arranged whole-close magnetic actuator composed of top and bottom bearings, an inner magnetic drive shaft, a combined oar blade groupware, a sealing groove without magnetism to separate outside and inner shaft, an outer alnico, and a lead-magnetic cylinder; a mixing chamber connected to said actuator by pipe line, a gas supply system connected to said chamber by pipe line. This invention isolates the gate that microbe and other pollutants enter into said bioreactor to eliminate pollution chance, and has strong power to satisfy development require.

Description

technical field [0001] The invention relates to a bioreactor system, in particular to a bioreactor system for large-scale animal cell culture. technical background [0002] Since the 1980s, great achievements have been made in animal cell genetic engineering and cell fusion technology, making it possible to express and produce various biologically active proteins such as monoclonal antibodies, vaccines, and growth factors for diagnosis and treatment through in vitro culture of animal cells. Since these proteins and monoclonal antibodies have very clear curative effects and have very broad market application prospects, the mass production of these high-value drugs using animal cell in vitro culture technology has become an important part of the biomedical high-tech industry and is the current development and production of new drugs. important areas. [0003] Applying a modern bioreactor system to replace the original manual roller bottle or square bottle culture system can g...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12M3/00
CPCC12M29/06C12M27/02
Inventor 谭文松顾小华朱明龙赵一鸣牛红星
Owner EAST CHINA UNIV OF SCI & TECH
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