Slow release tablet of containing active ingredient of ambroxol hydrochloride

Abstract

A slowly-releasing tablet with the release time of 8-24 hr contains ambroxol hydrochloride and slow-releasing material in the weight ratio of 1: (0.5-10).

Description

technical field [0001] The invention belongs to the field of drug sustained-release preparations, and more specifically relates to a sustained-release tablet of ambroxol hydrochloride, a medicine for reducing mucus and expectorant. Background technique [0002] The chemical name of ambroxol hydrochloride is: trans 4-[(2-amino-3,5-dibromo-phenyl)methyl-amino]cyclohexanol hydrochloride. For its preparation method, refer to GB1991, 2239242. has the following structure: [0003] [0004] Ambroxol hydrochloride is a new generation of airway mucus regulator, which has excellent expectorant effect and can significantly promote the synthesis and secretion of alveolar surfactant. Ambroxol hydrochloride can stimulate bronchial mucus glands to secrete more flowable mucus, dilute sputum, reduce viscosity, and increase the production and secretion of pulmonary surfactant, thereby reducing airway resistance, reducing mucus adhesion, and activating Mucociliary blanket functions to fa...

AI Technical Summary

Problems solved by technology

[0006] Due to the many times of taking medicine of ordinary tablets and capsules, the side effects are large, and the phenomenon of patients missing doses is prone to occur, and the blood drug concentration is not stable, and the duration of action is short; injections are inconvenient for patients to take medicine; sustained-release capsules and osmotic pump dosage forms Although the above shortcomings are overcome, the production process is complicated and the equipment requirements are high

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