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Soybean isoflavone phospholipid composition and preparation method thereof

A technology of isoflavone phospholipid and soybean isoflavone, applied in the field of medicine, can solve the problems of hindering the absorption and efficacy of soybean isoflavone, low availability of soybean isoflavone, poor water solubility of soybean isoflavone, etc. Solve the effect of being difficult to be absorbed and improve water solubility

Inactive Publication Date: 2006-07-12
TIANJIN ZHONGXIN PHARMA GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, during the application process, it was found that soy isoflavones have poor water solubility, which makes the bioavailability of soy isoflavones not high, thus hindering the absorption and efficacy of soy isoflavones

Method used

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  • Soybean isoflavone phospholipid composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Weigh 100 g of soybean lecithin and 200 g of soybean isoflavones, add 5000 ml of acetone, heat in a water bath (30° C.) and stir for about two hours to form a clear solution, filter off the solvent, and evaporate to dryness under reduced pressure to obtain 256 g of a milky yellow solid, namely Finished product of soy isoflavone phospholipid complex.

Embodiment 2

[0030] Weigh 2 g of soybean lecithin and 2 g of soybean isoflavones, add 50 ml of ethanol, heat in a water bath (about 40°C) and stir for about two hours to form a clear solution, filter off the solvent, and evaporate to dryness under reduced pressure to obtain 3.5 g of a milky yellow solid, That is the finished product of soybean isoflavone phospholipid complex.

Embodiment 3

[0032] Weigh 3 g of soybean lecithin and 1.5 g of soybean isoflavone, add 50 ml of tetrahydrofuran, heat in a water bath (about 50°C) and stir for about two hours to form a clear solution, filter off the solvent, and evaporate to dryness under reduced pressure to obtain 3.04 g of a milky yellow solid , the finished product of soybean isoflavone phospholipid complex.

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Abstract

The invention provides a soybean isoflavone and phosphatide compound and its preparing process, wherein the molar ratio of soybean isoflavone and phosphatide is 0.5-2 : 1. The preparing process consists of charging organic solvent with low dielectric constant into the mixture, stirring and mixing, filtering the solvent, finally subjecting the filter liquor to decompression drying or freeze drying.

Description

technical field [0001] The invention belongs to the field of medicine, in particular to a soybean isoflavone phospholipid compound and a preparation method thereof. Background technique [0002] Soybean isoflavones are mainly derived from leguminous plants, including soybean isoflavone glycosides and soybean isoflavone aglycones. The main components include genistein (Genistein), genistein (Genistin), daidzein (Daidzein), daidzein (Daidzin) and so on. Their structural formula is as follows: [0003] [0004] Compound name R 1 R 2 R 3 R 4 R 5 Daidzein H H OH OH H Genistein OH H OH OH H Glycitein H OCH 3 OH OH H Daidzin H H O-glucoside OH H Genistin H H O-glucoside OH H Glycitin H OCH 3 O-glucoside OH H [0005] Soy isoflavones h...

Claims

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Application Information

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IPC IPC(8): A61K31/661A61K31/7048A61K47/48A61P15/12A61P19/10A61P35/00A61P3/06A61K47/54
Inventor 潘勤刘稚菲孙琳
Owner TIANJIN ZHONGXIN PHARMA GRP CO LTD
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