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Doramectin injection fluid containing soyban oil

A doramectin and injection technology, applied in the field of doramectin injection and its preparation, can solve problems such as irritation, and achieve the effects of long-lasting drug effect, fast absorption and good stability

Active Publication Date: 2006-08-30
HISUN PHARMACEUTICAL (HANGZHOU) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, propylene glycol is known to cause irritation when injected subcutaneously or intramuscularly; also, small amounts of water in it can cause hydrolysis of the active ingredient

Method used

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  • Doramectin injection fluid containing soyban oil

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Embodiment 1: Preparation of doramectin injection

[0034] Prepare the injection with the following ingredients, mix ethyl oleate and soybean oil for injection, heat to 80°C, purging with nitrogen at the same time, add doramectin and BHA, stir to dissolve, quickly cool to room temperature, add Phenol, stir evenly, add soybean oil for injection to 1ml, stir evenly, filter and sterilize with a 0.22μm filter membrane, fill in a dry molded antibiotic glass bottle in a 100-grade sterile field, cover with sterilized and dried glue Plugs, aluminum caps, crimped caps and seals, packaged, delivered to the warehouse after passing the inspection.

[0035] Doramectin 10mg

[0036] Ethyl oleate 0.1ml

[0037] Phenol 2.5mg

[0038] tert-butyl-4-hydroxyanisole 0.2mg

[0039] Add soybean oil for injection to 1.00ml

Embodiment 2

[0040] Embodiment 2: Preparation of doramectin injection

[0041] Adopt the preparation method of implementation 1, only change the prescription amount of doramectin to 1 mg, and prepare qualified doramectin injection.

Embodiment 3

[0042] Embodiment 3: preparation doramectin injection

[0043] Adopt the preparation method of implementation 1, only change the prescription amount of doramectin to 20 mg, prepare qualified doramectin injection.

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Abstract

A doractin injection containing soybean oil is prepared from doracin, ethyl oleate, phenol, BHA and the soybean oil for injection. Its advantages are fast absorption, high durability and high stability.

Description

technical field [0001] The invention relates to a veterinary preparation for treating parasitic diseases, in particular to a doramectin injection using soybean oil as a solvent for treating parasitic diseases and a preparation method thereof. Background technique [0002] Doramectin (Doramectin, CAS accession number is 117704-25-3) is an abamectin animal antiparasitic drug, and its chemical name is 25-cyclohexyl-5-O-desmethyl-25-to( 1-Methylpropyl) Abamectin A 1a , the structural formula is as follows: [0003] [0004] This compound is a kind of avermectins, and U.S. Patent US5089480A protects this compound, and shows that this compound is a highly active antiparasitic agent, and can be used as an anthelmintic, ectoparasiticide, insecticide and Acaricide. [0005] The most common formulations for administration of antiparasitic agents to animals are parenteral formulations. Generally, water is a convenient injection liquid, but the solubility of abamectins in water i...

Claims

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Application Information

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IPC IPC(8): A61K47/44A61K31/7048A61P33/14A61K47/14
Inventor 高华廖建维杜加秋
Owner HISUN PHARMACEUTICAL (HANGZHOU) CO LTD
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