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Extractive of total benzofuran of benzoin plants, prepn. method and use thereof

A plant extract, benzofuran technology, applied in the direction of plant raw materials, plant/algae/fungi/moss components, sugar derivatives, etc.

Active Publication Date: 2006-09-13
CHENGDU DIAO PHARMA GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Some studies have reported that its benzofuran components have certain antibacterial activity. There is no total benzofuran extract from benzoin plants and its treatment of premature ovarian failure, menopausal syndrome, osteoporosis, and puberty ovarian hypofunction and polycystic ovary. Syndromes, infertility, and diseases caused by estrogen deficiency or relative insufficiency related literature records or research reports

Method used

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  • Extractive of total benzofuran of benzoin plants, prepn. method and use thereof
  • Extractive of total benzofuran of benzoin plants, prepn. method and use thereof
  • Extractive of total benzofuran of benzoin plants, prepn. method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] Example 1 Preparation of Washan Benzoin Extract 1

[0058] Wash 1000 g of dried benzoin seeds, crush it, add 8 L of 80% ethanol solution, heat and reflux for extraction for 1.5 hours, add 6 L of 80% ethanol solution to the filter residue, heat and reflux for 1 hour, and filter. The two filtrates were combined and concentrated under reduced pressure to obtain 248 g of total extract. Dissolve the total extract with 2L of hot water; take 2.5kg of D101 macroporous resin and pack it into a column, absorb the extract dissolved in hot water with macroporous resin, elute with 20L of water, discard the eluent, and then use 95% The column was eluted with ethanol, and the eluate was concentrated under reduced pressure to obtain an extract, which was then vacuum or freeze-dried to obtain 226 g of dry powder, which was analyzed by HPLC and determined to have a total benzofuran content of about 40% of the total weight.

Embodiment 2

[0059] Example 2 Preparation of Washan Benzoin Extract 2

[0060] Wash 1000 g of dried benzoin seeds, crush them, add 8 L of 80% ethanol solution, heat and reflux for extraction for 1.5 hours, add 6 L of 75% ethanol solution to the filter residue, heat and reflux for 1 hour, and filter. The two filtrates were combined and concentrated under reduced pressure to obtain 250 g of total extract. After dissolving the total extract with 2L hot water, extract 5 times with 3L industrial petroleum ether. Take 2 kg of D101 macroporous resin and pack it into a column. After the water layer is absorbed by the macroporous resin, it is eluted with 15 L of water. The eluent is discarded, and then the column is eluted with 75% ethanol. The eluent is concentrated under reduced pressure to obtain an extract , and then vacuum or freeze-dried to obtain 106 g of dry powder, which was analyzed by HPLC and determined to have a total benzofuran content of 90% of the total weight.

Embodiment 3

[0061] Example 3 Preparation of Luchun Benzoin Extract

[0062] Luchun benzoin dried seeds 1000g, crushed, add 8L of 80% ethanol solution, extract by heating and reflux for 1.5 hours, add 6L of 50% ethanol solution to the filter residue, extract by heating and reflux for 1 hour, and filter. The two filtrates were combined and concentrated under reduced pressure to obtain 203 g of total extract. Dissolve the total extract with 2L of hot water; take 2.5kg of D101 macroporous resin and pack it into a column, absorb the extract dissolved in hot water with macroporous resin, elute with 20L of water, discard the eluent, and then use 20% The column was eluted with ethanol, and the eluate was concentrated under reduced pressure to obtain an extract, which was then vacuum or freeze-dried to obtain 196 g of dry powder, which was analyzed by HPLC and determined to have a total benzofuran content of about 45% of the total weight.

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Abstract

A general benzifuran is extracted from the Styrax plant and can be used to prepared injection, tablet, capsule, etc for preventing and treating early failure of ovary function, climacteric syndrome, osteoporosis, polycystic overy syndrome, acyesis, etc. Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to a traditional Chinese medicine extract and its preparation method and use, in particular to a benzoin plant extract and its preparation method and use. Background technique [0002] Estrogen (especially estrogen E 2 ) is one of the most important hormones in humans and other higher animals, and has a wide range of physiological functions. 90% of premenopausal women have E 2 , 50%E 1 They come from the ovaries and adrenal glands respectively. Due to ovarian atrophy in postmenopausal women, the ovarian function is significantly reduced, so the secretion of estrogen is greatly reduced. At this time, the estrogen produced by fat cells becomes the main source of estrogen in the body. If this source is insufficient, E in the blood 1 ,E 2 It is only equivalent to the level of premenopausal women in the early follicular phase, which can easily lead to decreased bone density and osteoporotic fractures. Assuming that the average lif...

Claims

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Application Information

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IPC IPC(8): C07D405/04C07H15/26A61K31/7048A61K36/185A61K9/08A61K9/10A61K9/20A61K9/48A61P15/12A61P15/10A61P19/10A61K131/00
Inventor 高小平李麒麟张国林苏芝李伯刚及元乔刘忠荣
Owner CHENGDU DIAO PHARMA GROUP
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