Motherwort wort drip pills and prepn. method

A technology of motherwort and grass dripping pills, which is applied in the direction of pill delivery, pharmaceutical formulations, and medical preparations containing active ingredients, etc., can solve the problems of hepatic and intestinal first-pass effect bioavailability, affect the therapeutic effect, and low bioavailability, and achieve Avoid the first-pass effect, the process is reasonable, and the effect of high bioavailability

Inactive Publication Date: 2006-09-20
BEIJING BORAN PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Motherwort has an important and extensive application in the field of traditional medicine in my country, but most of the oral preparations made from motherwort alone have problems such as poor absorption and low bioavailability, such as long dissolution time, low dissolution rate, Problems such as slow absorption, hepatic and intestinal first-pass effect and low bioavailability affect the efficacy of the drug and directly affect the therapeutic effect

Method used

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  • Motherwort wort drip pills and prepn. method
  • Motherwort wort drip pills and prepn. method
  • Motherwort wort drip pills and prepn. method

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0039] Example 1: drug and matrix ratio test

[0040] Fix the drop distance (about 6cm), the length of the condensation column (80cm), the gradient cooling liquid (the temperature of the upper part of the temperature is 30±2°C, the temperature of the lower part of the nozzle is 10±2°C), the temperature of the oil bath is 100±5°C, and then Carry out combination test, take the smooth roundness of dropping pill as the investigation index, the results are shown in Table 1

[0041] Polyethylene glycol-4000

polyethylene glycol 1500

Polyethylene glycol-6000

matrix with

drug ratio

drop system

temperature °C

smooth round

Integer rate (%)

matrix with

drug ratio

drop system

temperature °C

smooth round

Integer rate (%)

matrix with

drug ratio

drop system

temperature °C

smooth round

Integer rate (%)

1.2∶1

1.2∶1

1.6∶1

1.6∶1

2.0∶1

2.0∶1

95±2

110±2

95±2...

example 2

[0044] Example 2: The way to add the drug to the matrix is ​​selected

[0045] Fixed drop distance (about 6cm), condensation column length (80cm), gradient cooling liquid (temperature at the upper part is 30+2℃, temperature at the lower part of the nozzle is 10±2℃), oil bath temperature is 100±5℃, substrate and The ratio of the drug was 8:5, the dropping temperature was 95±2°C, and the drug was added to the molten matrix in stages. The test results are shown in Table 2.

[0046] Feeding method

[0047] After the drug is added at one time, due to the large amount of drug, it is difficult to mix evenly. The appearance of the dropping pill is often rough, and the formability is not good. When the drug is added to the molten matrix in stages, it can be fully stirred. The smooth rounding rate is also high.

example 3

[0048] Example 3: Experiments with different dripper temperatures

[0049] The drug was added to the molten Matrix comparison, the test results are shown in Table 3.

[0050] Substrate: drug

[0051] When the dropping pills enter the condensate, the temperature of the coolant (20cm) is too low (20±2°C), and the prepared dropping pills often have voids or irregular pill shapes; when the temperature is too high (45±2°C), The density of the coolant here is low, the sinking speed of the prepared drop pills is too fast, and cannot be fully cooled, and flat pills or adhesions often occur; when the temperature of the coolant is controlled to 30±2°C, the roundness of the obtained drop pills is relatively high , The pill shape is smooth, therefore, the coolant should be controlled at 30±2°C.

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Abstract

A drippling pill of motherwort for treating menoxenia, puerperal metrorrhagia, subinvolution of uterus, etc is prepared from motherwort through extracting, adding matrix including polyethanediol 4000, heating, stirring and shaping.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine preparations, and in particular relates to a Motherwort dripping pill which has uterine contraction and is used for treating diseases such as menstruation regulation, postpartum uterine hemorrhage, and uterine incomplete recovery, and a preparation process thereof. Background technique [0002] Motherwort is the fresh or dried aerial part of Leonurus Japonicus Houtt, a plant of the Labiatae family, and is a traditional Chinese medicinal material. It has been recorded in past dynasties that fresh products are harvested from the seedling stage in spring to early summer flowering stage, and dry products are harvested in summer when the stems and leaves are lush and the flowers are not blooming or just blooming, and then dried or cut into sections and dried in the sun. Motherwort is bitter, pungent, and slightly cold, returns to the liver and pericardium meridian, and has the effects of pro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/533A61K9/20A61P15/00
Inventor 刘志勤彭丽丽黄成武单晓鹏张广林
Owner BEIJING BORAN PHARM CO LTD
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