Quercetin solid liposome nano particle preparation and its preparing method

A solid lipid nano and solid lipid technology, applied in the direction of liposome delivery, anti-toxic agent, anti-inflammatory agent, etc., can solve the problems of poor fat solubility, limit absorption, expand the clinical application of quercetin, etc., and achieve the preparation Simplicity, improved stability, enhanced dissolution and absorption effects

Active Publication Date: 2006-10-25
SHANDONG DYNE MARINE BIOTECHCAL PHARM HLDG CO LTD
View PDF0 Cites 15 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, quercetin is almost insoluble in water and poorly fat-soluble, which limits its absorption through biomembranes and makes it have low oral bioavailability
Therefore, at present, improving the oral absorption of quercetin is the bottleneck to expand the clinical application of quercetin and make its further large-scale production

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Quercetin solid liposome nano particle preparation and its preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Accurately weigh 20 mg of quercetin, 200 mg of stearic acid, and 100 mg of lecithin, add them to 20 ml of a 1:1 mixed solvent of chloroform and acetone, and dissolve to form oil phase A. Measure 20ml of 30% ethanol solution, add 0.8g poloxamer 188 to form system B. Another 30ml of 30% ethanol solution was taken, and 1.2g of poloxamer 188 was added to form aqueous phase C, which was refrigerated until use. Heat A and B in a water bath to 70°C. After A completely dissolves into a clear liquid, pour A into B with stirring, and stir at constant temperature for 1 hour to completely volatilize the organic solvent to obtain light yellow emulsion D. Pour D into C (in an ice bath), and stir for 1 hour under ice bath conditions to obtain a pale yellow suspension E with obvious opalescence, and dilute E to 50ml with a solution of the same system as C to obtain quercetin Solid lipid nanoparticle suspension.

Embodiment 2

[0030] Accurately weigh 30 mg of quercetin, 200 mg of stearic acid, and 100 mg of sodium cholate, add 20 ml of a 1:1 mixed solvent of chloroform and ethanol, and dissolve to form oil phase A. Measure 20ml of distilled water and add 1g of polysorbate 80 to form System B. Another 30ml of distilled water was taken, and 802g of polysorbate was added to form aqueous phase C, which was refrigerated for later use. Heat A and B in a water bath to 70°C. After A completely dissolves into a clear liquid, pour A into B with stirring, and stir at constant temperature for 1 hour to completely volatilize the organic solvent to obtain light yellow emulsion D. Pour D into C (in an ice bath), and stir for 1 hour under ice bath conditions to obtain a pale yellow suspension E with obvious opalescence, and dilute E to 50ml with a solution of the same system as C to obtain quercetin Solid lipid nanoparticle suspension.

Embodiment 3

[0032]Accurately weigh 20 mg of quercetin, 100 mg of glyceryl monostearate, and 200 mg of soybean lecithin, add them to 20 ml of a 1:1 mixed solvent of chloroform and methanol, and dissolve to form oil phase A. Measure 20ml of 25% ethanol solution, add poloxamer 1880.8g to form system B. Another 30ml of 20% ethanol solution was taken, and 1.6g of poloxamer 188 was added to form aqueous phase C, which was refrigerated until use. Heat A and B in a water bath to 90°C. After A completely dissolves into a clear liquid, pour A into B with stirring, and stir at constant temperature for 1 hour to completely volatilize the organic solvent to obtain light yellow emulsion D. Pour D into C (in an ice bath), and stir for 1 hour under ice bath conditions to obtain a pale yellow suspension E with obvious opalescence, and dilute E to 50ml with a solution of the same system as C to obtain quercetin Solid lipid nanoparticle suspension.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The present invention relates to a quercetin solid lipid nano granule preparation and its preparation method, belonging to the field of medicine technology. Said invention uses quercetin as raw material medicine, adopts the mixture of solid lipid, emulsifier and emulsification adjuvant as medicine carrier and utilizes a certain preparation process so as to obtain the invented product. Said invention also provides the concrete steps of said preparation process.

Description

(1) Technical field [0001] The invention relates to a quercetin solid lipid nanoparticle preparation and a preparation method thereof. (2) Background technology [0002] Quercetin (Quercetin, QT) is a natural flavonoid compound, the chemical name is pentahydroxyflavone, and its synonym is quercetin and quercetin. Quercetin and its derivatives are widely found in vegetables, fruits, dried fruits, beverages and Chinese herbal medicines, and are an important physiologically active substance in food and Chinese herbal medicines. When quercetin enters the body, it can interact with proteins, and has various biological activities and pharmacological effects such as dilating coronary blood vessels, lowering blood lipids, anti-platelet aggregation, anti-cancer, anti-free radicals, anti-anemia, anti-inflammation, and anti-allergy. Quercetin and its derivatives have broad application prospects in medicine, food, cosmetics and other fields. However, quercetin is almost insoluble in w...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61K9/10A61K9/127A61K9/14A61P7/06A61P29/00A61P35/00A61P37/08A61P39/06
Inventor 翟光喜李厚丽娄红祥马玉坤
Owner SHANDONG DYNE MARINE BIOTECHCAL PHARM HLDG CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap