3-amido substituted nenzoyl urea compound, and its antitumor action

A compound and anti-tumor drug technology, applied in the field of microtubule and microfilament inhibitor benzoyl urea small molecule derivatives, can solve the problems such as the anti-tumor effect of compounds that have not yet been seen, and achieve the effect of strong cell killing activity
CN1850794AInactive Publication Date: 2006-10-25MEDICINE & BIOENG INST OF CHINESE ACAD OF MEDICAL SCI
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
MEDICINE & BIOENG INST OF CHINESE ACAD OF MEDICAL SCI
Publication Date
2006-10-25
Estimated Expiration
Not applicable · inactive patent

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Abstract

This invention relates to new style 3-acylamino substituted benzoyl urea kind compound. On base of deep research of structure activity, benzene ring mother nuclide, 1 bit acyl urea side chain and 3 bit acyl urea side chain are differently replaced to synthesize series derivant. Good compound is selected from the derivant, and it has strong activity revealed by anti tumor experiment, and toxicity is low, so it is convenient to synthesize, and anti medicine capability is hard form, so it has good application prospect.
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Description

Technical field:

[0001] The invention relates to a microtubule microfilament inhibitor benzoylurea small molecule derivative and its antitumor effect. Background technique:

[0002] Tumor is one of the malignant and stubborn diseases that are difficult to deal with, and it has become the second "killer" in the world after cardiovascular disease. According to the statistics of the World Health Organization, in 2000, the number of new cancer cases in the world exceeded 10 million, and the number of deaths was 6.2 million. In 2004, the number of patients exceeded 22 million. In 2020, the number of new cancer cases worldwide will reach 15 million and 10 million will die. According to literature reports, in addition to the bioengineering drugs (including anti-cancer vaccines) such as monoclonal antibodies, tumor necrosis factors, interferons, and interleukins that have been marketed, the anti-tumor drugs that are currently under development include the following 8 categories: ①A...

Claims

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